ArticleThe Journal of physiology2014
Assessment of in vivo skeletal muscle mitochondrial respiratory capacity in humans by near-infrared spectroscopy: a comparison with in situ measurements.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus
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Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
Non-invasive Evaluation of Muscle Oxidative Capacity. Study of Its Relationship With Muscular Endurance and Fatigue in Patients With Multiple Sclerosis
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Muscle Oximetry in Sports Science: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Effect of live-high, train-low strategy induced by chronic low-dose carbon monoxide exposure on haematological parameters and performance in trained individuals.Experimental physiology · 2026Trial
- Exercise training-induced speeding ofEuropean journal of applied physiology · 2025Trial
- Muscle mitochondrial capacity in high- and low-fitness females using near-infrared spectroscopy.Physiological reports · 2021Trial
- The effect of dietary nitrate on exercise capacity in chronic kidney disease: a randomized controlled pilot study.Nitric oxide : biology and chemistry · 2021Trial
- Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake.The Journal of physiology · 2016Trial
- Near infrared spectroscopy-derived muscle oxidative capacity correlates to oxidative metabolic predictors of performance in highly trained female middle-distance runners.Physiological reports · 2026Article
- Preserved muscle oxidative capacity in COPD patients with hypoxemia treated by long term OEuropean journal of applied physiology · 2026Article
- Skeletal muscle microvascular and respiratory responses to exercise in healthy and T2D adults: agreement and reproducibility study of NIRS technologies.European journal of applied physiology · 2026Article
- One half of the sprinting coin: the oxygen transport cascade of a 91-yr-old female world-record sprinter.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- The impact of muscle oxidative capacity on neuromuscular recovery after exercise-induced muscle damage.European journal of applied physiology · 2026Article
- Muscle oxidative capacity does not appear to influence NIRS-VOT outcomes in healthy adults.European journal of applied physiology · 2026Article
- Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS-CoV-2 infection.Experimental physiology · 2026Article
- Steepest near-infrared spectroscopy-derived deoxygenation slopes during arterial occlusions provide more reliable assessments of muscle mitochondrial capacity.Experimental physiology · 2026Article
- Cardiorespiratory and vascular function outcomes following 4 weeks of single-sprint training.Frontiers in physiology · 2026Article
- Protocol for non-invasive assessment of skeletal muscle structure and function in adolescents with single ventricle heart disease: a cross-sectional, case-control study.Frontiers in cardiovascular medicine · 2026Article
- Oxidative and OExperimental physiology · 2025Article
- The slow component of oxygen uptake of insulated muscular groups measured with NIRS during intermittent isometric contractions in humans.Physiological reports · 2025Article
- Muscle oxidative capacity but not specific force is greater in aerobic versus resistance trained young adults.European journal of applied physiology · 2025Article
- Impact of sprint interval training on post-fatigue mitochondrial rate in professional boxers.European journal of applied physiology · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The present study aimed to compare in vivo measurements of skeletal muscle mitochondrial respiratory capacity made using near-infrared spectroscopy (NIRS) with the current gold standard, namely in situ measurements of high-resolution respirometry performed in permeabilized muscle fibres prepared from muscle biopsies. Mitochondrial respiratory capacity was determined in 21 healthy adults in vivo using NIRS to measure the recovery kinetics of muscle oxygen consumption following a ∼15 s isometric contraction of the vastus lateralis muscle. Maximal ADP-stimulated (State 3) respiration was measured in permeabilized muscle fibres using high-resolution respirometry with sequential titrations of saturating concentrations of metabolic substrates. Overall, the in vivo and in situ measurements were strongly correlated (Pearson's r = 0.61-0.74, all P < 0.01). Bland-Altman plots also showed good agreement with no indication of bias. The results indicate that in vivo NIRS corresponds well with the current gold standard, in situ high-resolution respirometry, for assessing mitochondrial respiratory capacity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.