ArticleThe Journal of physiology2014
Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed.
- Dual cholinergic mechanisms for sculpting striatal dopamine in vivo.bioRxiv : the preprint server for biology · 2025Article
- An axonal brake on striatal dopamine output by cholinergic interneurons.Nature neuroscience · 2025Article
- Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks.International journal of molecular sciences · 2023Review
- Acetylcholine waves and dopamine release in the striatum.Nature communications · 2023Article
- Article
- Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation.eLife · 2023Article
- Article
- Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers.Neuron · 2022Article
- Effectiveness and Relationship between Biased and Unbiased Measures of Dopamine Release and Clearance.ACS chemical neuroscience · 2022Article
- An action potential initiation mechanism in distal axons for the control of dopamine release.Science (New York, N.Y.) · 2022Article
- Binge alcohol drinking alters the differential control of cholinergic interneurons over nucleus accumbens D1 and D2 medium spiny neurons.Frontiers in cellular neuroscience · 2022Article
- Spatial and temporal scales of dopamine transmission.Nature reviews. Neuroscience · 2021Review
- Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.Frontiers in cellular neuroscience · 2021Article
- Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.Nature communications · 2019Article
- Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating CaACS chemical neuroscience · 2019Article
- Mechanisms and regulation of dopamine release.Current opinion in neurobiology · 2019Review
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method.Journal of visualized experiments : JoVE · 2018Article
- Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cholinergic Interneurons Underlie Spontaneous Dopamine Release in Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Striatal dopamine (DA) is critically involved in major brain functions such as motor control and deficits such as Parkinson's disease. DA is released following stimulation by two pathways: the nigrostriatal pathway and the cholinergic interneuron (ChI) pathway. The timing of synaptic transmission is critical in striatal circuits, because millisecond latency changes can reverse synaptic plasticity from long-term potentiation to long-term depression in a DA-dependent manner. Here, we determined the temporal components of ChI-driven DA release in striatal slices from optogenetic ChAT-ChR2-EYFP mice. After a light stimulus at room temperature, ChIs fired an action potential with a delay of 2.8 ms. The subsequent DA release mediated by nicotinic acetylcholine (ACh) receptors had a total latency of 17.8 ms, comprising 7.0 ms for cholinergic transmission and 10.8 ms for the downstream terminal DA release. Similar latencies of DA release were also found in striatal slices from wild-type mice. The latency of ChI-driven DA release was regulated by inhibiting the presynaptic vesicular ACh release. Moreover, we describe the time course of recovery of DA release via the two pathways and that of vesicle replenishment in DA terminals. Our work provides an example of unravelling the temporal building blocks during fundamental synaptic terminal-terminal transmission in motor regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.