ArticleOncotarget2014
Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
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- Applications and continued evolution of glycan imaging mass spectrometry.Mass spectrometry reviews · 2023Review
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- Linc01133 promotes proliferation and metastasis of human renal cell carcinoma through sponging miR-760.Cell cycle (Georgetown, Tex.) · 2022Article
- Single cell mass spectrometry studies reveal metabolomic features and potential mechanisms of drug-resistant cancer cell lines.Analytica chimica acta · 2022Article
- GeneChip expression profiling identifiedAnnals of translational medicine · 2022Article
- Fucosylation in Urological Cancers.International journal of molecular sciences · 2021Review
- NF-κB pathway play a role in SCD1 deficiency-induced ceramideCancer biology & therapy · 2021Article
- Intratumoral Genomic Heterogeneity May Hinder Precision Medicine Strategies in Patients with Serous Ovarian Carcinoma.Diagnostics (Basel, Switzerland) · 2020Article
- Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry.Journal of mass spectrometry : JMS · 2020Article
- Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas.BMC cancer · 2019Article
- G6PD promotes renal cell carcinoma proliferation through positive feedback regulation of p-STAT3.Oncotarget · 2017Article
- Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach.Oncotarget · 2017Article
- Multi-omics approach reveals the secrets of metabolism of clear cell-renal cell carcinoma.Translational andrology and urology · 2016Article
- Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis.Scientific reports · 2016Article
- Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma.PloS one · 2016Article
- Observational
- Article
- LowerCancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Currently there is a lack of targeted therapies that lead to long-term attenuation or regression of disease in patients with advanced clear cell renal cell carcinoma (ccRCC). Our group has implemented a high-throughput genetic analysis coupled with a high-throughput proliferative screen in order to investigate the genetic contributions of a large cohort of overexpressed genes at the functional level in an effort to better understand factors involved in tumor initiation and progression. Patient gene array analysis identified transcripts that are consistently elevated in patient ccRCC as compared to matched normal renal tissues. This was followed by a high-throughput lentivirus screen, independently targeting 195 overexpressed transcripts identified in the gene array in four ccRCC cell lines. This revealed 31 'hits' that contribute to ccRCC cell proliferation. Many of the hits identified are not only presented in the context of ccRCC for the first time, but several have not been previously linked to cancer. We further characterize the function of a group of hits in tumor cell invasion. Taken together these findings reveal pathways that may be critical in ccRCC tumorigenicity, and identifies novel candidate factors that could serve as targets for therapeutic intervention or diagnostic/prognostic biomarkers for patients with advanced ccRCC.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.