ArticleJournal of neurophysiology2014
Region-specific regulation of voltage-gated intrinsic currents in the developing optic tectum of the Xenopus tadpole.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Serotonin Strengthens a Developing Glutamatergic Synapse through a PI3K-Dependent Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Characterization of NaLife science alliance · 2024Article
- Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity ineLife · 2021Article
- Homeostatic plasticity in neural development.Neural development · 2018Review
- Preparations and Protocols for Whole Cell Patch Clamp Recording of Xenopus laevis Tectal Neurons.Journal of visualized experiments : JoVE · 2018Article
- A population of gap junction-coupled neurons drives recurrent network activity in a developing visual circuit.Journal of neurophysiology · 2016Article
- Article
- Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The horizontal brain slice preparation: a novel approach for visualizing and recording from all layers of the tadpole tectum.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Across the rostrocaudal (RC) axis of the Xenopus tadpole optic tectum exists a developmental gradient. This gradient has served as a useful model to study many aspects of synapse and dendrite maturation. To compliment these studies, we characterized how the intrinsic excitability, the ease in which a neuron can fire action potentials, might also be changing across the same axis. Whole-cell recordings from tectal neurons at different points along the RC axis revealed a graded increase in intrinsic excitability: compared with neurons at the caudal end of the tectum, neurons at the rostral end fired more action potentials in response to current injection and expressed greater peak Na⁺ and K⁺ currents, the major intrinsic currents in these neurons that underlie the action potential. We also observed, along the same axis and in the same direction, a previously described increase in the amount of synaptic drive received by individual neurons (Wu GY, Malinow R, Cline HT. Science 274: 972-976, 1996). Thus as synaptic activity ramps up across the RC axis, so does intrinsic excitability. The reduction of overall circuit activity induced a compensatory scaling up of peak Na⁺ and K⁺ currents only in the caudal portion of the tectum, suggesting a region-specific, compensatory form of plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.