Evidence map›Paper›PMID 25019163›Full record

SynthesisPloS one2014

Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies.

Judith S Brand, Maroeska M Rovers, Bu B Yeap, Harald J Schneider, Tomi-Pekka Tuomainen, Robin Haring, Giovanni Corona, Altan Onat, Marcello Maggio, Claude Bouchard and 19 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 7 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 7 syntheses or guidelines pooled it, 208 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 13 countries.

Judith S BrandJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Maroeska M RoversJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Departments of EBH and operating rooms, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Bu B YeapSchool of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Harald J SchneiderMedizinische Klinik Innenstadt der Universität München, München, Germany.
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Robin HaringInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Giovanni CoronaAndrology and Sexual Medicine Unit Department of Clinical Physiopathology, University of Florence, Florence, Italy.
Altan OnatDepartment of Cardiology, Istanbul University, Istanbul, Turkey.
Marcello MaggioDepartment of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy.
Claude BouchardPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America.
Peter C Y TongDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, Hong Kong.
Richard Y T ChenDepartment of Endocrinology, Changing General Hospital, Singapore, Singapore.
Masahiro AkishitaDepartment of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Jourik A GietemaDepartment of Medical Oncology, University Medical Center Groningen, Groningen, Netherlands.
Marie-Hélène Gannagé-YaredDepartment of Endocrinology, Saint-Joseph University, Beirut, Lebanon.
Anna-Lena UndénCenter for Family and Community Medicine, Stockholm, Sweden.
Aarno HautanenDepartment of Clinical Chemistry, University of Helsinki, Helsinki, Finland.
Nicolai P GoncharovEndocrinology Research Center, Moscow, Russia.
Philip KumanovClinical Center of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria.
S A Paul ChubbSchool of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Osvaldo P AlmeidaSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.
Hans-Ulrich WittchenInstitute of Clinical Psychology, Center of Clinical Epidemiology and Longitudinal Studies, University of Dresden, Dresden, Germany.
Jens KlotscheInstitute of Clinical Psychology, Center of Clinical Epidemiology and Longitudinal Studies, University of Dresden, Dresden, Germany.
Henri WallaschofskiInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Jussi KauhanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jukka T SalonenMAS-Metabolic Analytical Services Oy, Helsinki, Finland.
Luigi FerrucciClinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Universitätsmedizin Greifswald · DEUniversity of Western Australia · AUTU Dresden · DEUniversity Medical Center Utrecht · NLUniversity of Eastern Finland · FICentre for Palaeogenetics · SEChinese University of Hong Kong · CNEndocrinology Research Center · RUIstanbul University · TRMedical University of Sofia · BGMünchen Klinik · DENational Institute on Aging · USPennington Biomedical Research Center · USRadboud University Nijmegen · NLSaint Joseph University · LBThe University of Tokyo · JPUniversity Medical Center Groningen · NLUniversity of Florence · ITUniversity of Helsinki · FIUniversity of Parma · IT

Funding

Biomarkers of Homestatic Dysregulation in Aging and Chronic DiseaseZIAAG000971 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$1.9M
6 · The paper itself

Abstract

backgroundLow total testosterone (TT) and sex hormone-binding globulin (SHBG) concentrations have been associated with the metabolic syndrome (MetS) in men, but the reported strength of association varies considerably.

objectivesWe aimed to investigate whether associations differ across specific subgroups (according to age and body mass index (BMI)) and individual MetS components. DATA SOURCES: Two previously published meta-analyses including an updated systematic search in PubMed and EMBASE. STUDY ELIGIBILITY CRITERIA: Cross-sectional or prospective observational studies with data on TT and/or SHBG concentrations in combination with MetS in men.

methodsWe conducted an individual participant data meta-analysis of 20 observational studies. Mixed effects models were used to assess cross-sectional and prospective associations of TT, SHBG and free testosterone (FT) with MetS and its individual components. Multivariable adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated and effect modification by age and BMI was studied.

resultsMen with low concentrations of TT, SHBG or FT were more likely to have prevalent MetS (ORs per quartile decrease were 1.69 (95% CI 1.60-1.77), 1.73 (95% CI 1.62-1.85) and 1.46 (95% CI 1.36-1.57) for TT, SHBG and FT, respectively) and incident MetS (HRs per quartile decrease were 1.25 (95% CI 1.16-1.36), 1.44 (95% 1.30-1.60) and 1.14 (95% 1.01-1.28) for TT, SHBG and FT, respectively). Overall, the magnitude of associations was largest in non-overweight men and varied across individual components: stronger associations were observed with hypertriglyceridemia, abdominal obesity and hyperglycaemia and associations were weakest for hypertension.

conclusionsAssociations of testosterone and SHBG with MetS vary according to BMI and individual MetS components. These findings provide further insights into the pathophysiological mechanisms linking low testosterone and SHBG concentrations to cardiometabolic risk.

Indexed as

AdultAgedAged, 80 and overAge FactorsBody Mass IndexCross-Sectional StudiesHumansMaleMetabolic SyndromeMiddle AgedObservational Studies as TopicOdds RatioProspective StudiesSex Hormone-Binding GlobulinTestosteroneYoung AdultSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID25019163
PMCPMC4096400
OpenAlexW2150332645

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.