ArticleJournal of periodontal research2015
Increased and correlated expression of connective tissue growth factor and transforming growth factor beta 1 in surgically removed periodontal tissues with chronic periodontitis.
Article in Journal of periodontal research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Pooled it
- Drug-induced gingival overgrowth in renal transplants patients.Open medicine (Warsaw, Poland) · 2026Review
- Evaluation of the effects of Andiz extract on the experimentally wound in rats by microbiological and gene expression methods.Molecular biology reports · 2024Article
- Pathogenesis of periodontitis - A potential role for epithelial-mesenchymal transition.The Japanese dental science review · 2022Review
- Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens.Lasers in medical science · 2021Article
- Periodontal tissue regeneration combined with orthodontic treatment can improve clinical efficacy and periodontal function of patients with periodontitis.American journal of translational research · 2021Article
- Salivary proteomic profile of dogs with and without dental calculus.BMC veterinary research · 2020Article
- Connective tissue growth factor (CTGF) regulates the fusion of osteoclast precursors by inhibiting Bcl6 in periodontitis.International journal of medical sciences · 2020Article
- Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview.BMC oral health · 2019Review
- Smad6 Methylation Represses NFκB Activation and Periodontal Inflammation.Journal of dental research · 2018Article
- Buccal Mucosal Epithelial Cells Downregulate CTGF Expression in Buccal Submucosal Fibrosis Fibroblasts.Journal of maxillofacial and oral surgery · 2018Article
- Comparative evaluation of IL-17 and TGF-β expression in tissues of patients with chronic periodontitis and healthy individuals using real-time PCR.Journal of advanced periodontology & implant dentistry · 2018Article
- Periodontal CD14 mRNA expression is downregulated in patients with chronic periodontitis and type 2 diabetes.BMC oral health · 2015Article
- Transforming growth factor-β1 rs1800469 polymorphism and periodontitis risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.PloS one · 2014Article
- Association of TGF-β1 with periodontitis patients in north Indian population.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveBoth gingival tissue destruction and regeneration are associated with chronic periodontitis, although the former overwhelms the latter. Studies have shown that transforming growth factor beta 1 (TGF-β1), a growth factor largely involved in tissue regeneration and remodeling, is upregulated in chronic periodontitis. However, the gingival expression of connective tissue growth factor (CTGF or CCN2), a TGF-β1-upregulated gene, in patients with periodontitis remains undetermined. Although both CTGF/CCN2 and TGF-b1 increase the production of extracellular matrix, they have many different biological functions. Therefore, it is important to delineate the impact of periodontitis on gingival CTGF/CCN2 expression. MATERIAL AND
methodsPeriodontal tissue specimens were collected from seven individuals without periodontitis (group 1) and from 14 with periodontitis (group 2). The expression of CTGF and TGFβ1 mRNAs were quantified using real-time PCR.
resultsAnalysis using the nonparametric Mann-Whitney U-test showed that the levels of expression of both CTGF/CCN2 and TGFβ1 mRNAs were significantly increased in individuals with periodontitis compared with individuals without periodontitis. Furthermore, analysis using a nonparametric correlation (Spearman r) test showed a positive correlation between TGFβ1 and CTGF/CCN2 mRNAs.
conclusionThe gingival expression levels of CTGF/CCN2 and TGFβ1 mRNAs in individuals with periodontitis are upregulated and correlated.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.