ArticleThe Journal of biological chemistry2014
Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Beyond the first bout: Adaptations to repeated injuries across physiological and pathological conditions.Physiological reports · 2026Review
- Phosphorylation of RYR1 at SerScience signaling · 2025Article
- Creation of knockin mice for the fluorescence protein based in vivo identification of skeletal myofiber types.Scientific reports · 2025Article
- Article
- Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency.The Journal of general physiology · 2025Article
- Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.Communications biology · 2023Article
- Anabolic Function Downstream of TOR Controls Trade-offs Between Longevity and Reproduction at the Level of Specific TissuesFrontiers in aging · 2021Article
- Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Small calcium leaks, big muscle adaptations.The Journal of general physiology · 2019Article
- SR CaThe Journal of general physiology · 2019Article
- Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1.Human molecular genetics · 2018Article
- Muscle Weakness in Rheumatoid Arthritis: The Role of CaEBioMedicine · 2017Review
- A chemical chaperone improves muscle function in mice with a RyR1 mutation.Nature communications · 2017Article
- Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.The Journal of clinical investigation · 2017Article
- mTOR function and therapeutic targeting in breast cancer.American journal of cancer research · 2017Review
- The maintenance ability and CaExperimental & molecular medicine · 2016Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Funding
Abstract
Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes are found with SLF (synthetic ligand for FKBP12, which does not inhibit mTORC1) and in mice with a skeletal muscle-specific FKBP12 deficiency. These interventions also increase Ca(2+) influx to enhance refilling of sarcoplasmic reticulum Ca(2+) stores, slow muscle fatigue, and increase running endurance without negatively impacting cardiac function. FKBP12 deficiency or longer treatments with low dose rapamycin or SLF increase the percentage of type I fibers, further adding to fatigue resistance. We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.