Trial reportInternational journal of cardiology2014
Left ventricular diastolic function in relation to the urinary proteome: a proof-of-concept study in a general population.
Trial report in International journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Urinary Collagen Peptides Predict Mortality.Proteomics · 2026Article
- Association of Urinary Complement Peptides with Kidney Function and Progression of Kidney Disease.International journal of molecular sciences · 2026Article
- Development and Validation of a Capillary Electrophoresis Coupled to Mass Spectrometry Pipeline for Comparable Assessment of the Plasma Peptidome.Proteomics · 2025Article
- Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios.Journal of translational medicine · 2023Article
- Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Plasma and Urinary Biomarkers Improve Prediction of Mortality through 1 Year in Intensive Care Patients: An Analysis from FROG-ICU.Journal of clinical medicine · 2023Article
- Urinary Proteomic Profile of Arterial Stiffness Is Associated With Mortality and Cardiovascular Outcomes.Journal of the American Heart Association · 2022Article
- The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure.ESC heart failure · 2020Article
- Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction.Proteomics. Clinical applications · 2019Review
- Novel Urinary Biomarkers For Improved Prediction Of Progressive Egfr Loss In Early Chronic Kidney Disease Stages And In High Risk Individuals Without Chronic Kidney Disease.Scientific reports · 2018Article
- Utilizing proteomics to understand and define hypertension: where are we and where do we go?Expert review of proteomics · 2018Review
- Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction.Journal of the American Society of Hypertension : JASH · 2018Article
- Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study.Transplantation direct · 2018Article
- Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease.Journal of translational medicine · 2018Article
- Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients.PloS one · 2018Article
- Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction.PloS one · 2018Article
- A Urinary Fragment of Mucin-1 Subunit α Is a Novel Biomarker Associated With Renal Dysfunction in the General Population.Kidney international reports · 2017Article
- Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure.Journal of the American Heart Association · 2017Article
- Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)-Rationale and database description.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundIn previous studies, we identified two urinary proteomic classifiers, termed HF1 and HF2, which discriminated subclinical diastolic left ventricular (LV) dysfunction from normal. HF1 and HF2 combine information from 85 and 671 urinary peptides, mainly up- or down-regulated collagen fragments. We sought to validate these classifiers in a population study.
methodsIn 745 people randomly recruited from a Flemish population (49.8 years; 51.3% women), we measured early and late diastolic peak velocities of mitral inflow (E and A) and mitral annular velocities (e' and a') by conventional and tissue Doppler echocardiography, and the urinary proteome by capillary electrophoresis coupled with mass spectrometry.
resultsIn the analyses adjusted for sex, age, body mass index, blood pressure, heart rate, LV mass index and intake of medications, we expressed effect sizes per 1-SD increment in the classifiers. HF1 was associated with 0.204 cm/s lower e' peak velocity (95% confidence interval, 0.057-0.351; p=0.007) and 0.145 higher E/e' ratio (0.023-0.268; p=0.020), while HF2 was associated with a 0.174 higher E/e' ratio (0.046-0.302; p=0.008). According to published definitions, 67 (9.0%) participants had impaired LV relaxation and 96 (12.9%) had elevated LV filling pressure. The odds of impaired relaxation associated with HF1 was 1.38 (1.01-1.88; p=0.043) and that of increased LV filling pressure associated with HF2 was 1.38 (1.00-1.90; p=0.052).
conclusionsIn a general population, the urinary proteome correlated with diastolic LV dysfunction, proving its utility for early diagnosis of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.