ArticleLipids in health and disease2014
Association of vitamin D receptor gene polymorphisms with metabolic syndrome: a case-control design of population-based cross-sectional study in North China.
Article in Lipids in health and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- VDR Gene variation and insulin resistance related diseases.Lipids in health and disease · 2017Pooled it
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- The predictive accuracy of coronary heart disease risk prediction models in rural Northwestern China.Preventive medicine reports · 2023Article
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- Vitamin D-Related Single Nucleotide Polymorphisms as Risk Biomarker of Cardiovascular Disease.International journal of molecular sciences · 2022Article
- Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control.Genes & nutrition · 2022Article
- The Association Between FokI Vitamin D Receptor Polymorphisms With Metabolic Syndrome Among Pregnant Arab Women.Frontiers in endocrinology · 2022Article
- Obesity Metabolic Phenotype, Changes in Time and Risk of Diabetes Mellitus in an Observational Prospective Study on General Population.International journal of public health · 2022Observational
- Gene Polymorphisms Associated with Central Precocious Puberty and Hormone Levels in Chinese Girls.International journal of endocrinology · 2022Article
- Association of vitamin D receptor polymorphisms with metabolic syndrome-related components: A cross-sectional study.Journal of clinical laboratory analysis · 2021Article
- Beta cell function, insulin resistance and vitamin D status among type 2 diabetes patients in Western Kenya.Scientific reports · 2021Article
- The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile.Nutrition & diabetes · 2018Article
- Establishing a genetic link between FTO and VDR gene polymorphisms and obesity in the Emirati population.BMC medical genetics · 2018Article
- Relationship Between Vitamin D Status and Vitamin D Receptor Gene Polymorphisms With Markers of Metabolic Syndrome Among Adults.Frontiers in endocrinology · 2018Article
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- Vitamin D Receptor Gene Polymorphisms Are Associated with Abdominal Visceral Adipose Tissue Volume and Serum Adipokine Concentrations but Not with Body Mass Index or Waist Circumference in African Americans: The Jackson Heart Study.The Journal of nutrition · 2016Article
- Article
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11 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome (MS) increases a risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The Vitamin D Receptor gene (VDR) may be important for developing MS. The aim of this study is to investigate the correlation between the VDR gene polymorphisms and MS in North China.
methodsA case-control study included 391 participants with MS according to the MS diagnostic criteria of International Diabetes Federation 2005 (IDF2005) and 400 controls was conducted on the basis of a cross sectional study which was performed from 2008 to 2012 in Ningxia Hui Autonomous Region, China. Anthropometric data, blood pressure and blood samples were collected in the field investigation. Blood biochemistry analyses were carried out in the laboratory. Two single-nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410 A > G) and FokI (rs 2228570 C > T), were genotyped.
resultsThe difference in the occurrence of genotypes in BsmI between individuals with MS and the control group was significant. Compared with genotype Bb/bb and allele b, genotype BB and allele B showed higher frequencies in MS cases than controls, which suggested they were risk factors. In addition, the genotype BB carriers with MS presented a higher waist circumference, while genotype FF for the FokI polymorphism was correlated with lower BMI in subjects with MS.
conclusionOur study suggests that the VDR gene polymorphisms appear to be associated with MS in the Northern Chinese population. Allele B and BB genotype for BsmI are risk factors for MS. The BsmI polymorphism seems to influence waist circumference, while the FokI polymorphism influence BMI in subjects with MS.
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