ArticlePlant physiology2014
Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
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Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85 citing papers in PubMed, 154 citations in OpenAlex.
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
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- The SnRK1-RAP2.4h-PIP2 module contributes to the trade-off between growth and hypoxia tolerance in plants.Nature communications · 2026Article
- Comparative transcriptomics unveils the role of DELLA protein GAIP-B in cold tolerance of mango (Mangifera indica L.).BMC plant biology · 2026Article
- Advances in the Function Roles of Hydroxycinnamoyl-CoA Shikimate/Quinate Hydroxycinnamoyl Transferases: A Key Enzyme Linking Phenylpropanoid Metabolism to Plant Terrestrial Adaptation.Plants (Basel, Switzerland) · 2026Review
- Dynamic Coordination: How ERF Transcription Factors Coordinate Plant Development and Adaptive Stress Responses.Biomolecules · 2026Review
- Compound Inflorescence (S) represses fruit growth and seed development in tomato.Molecular horticulture · 2026Article
- Waterlogging and hypoxia in plant abiotic stress.Frontiers in plant science · 2026Review
- GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant.Nature chemical biology · 2025Article
- Transcriptomic Analysis Reveals Candidate Hub Genes and Putative Pathways inCurrent issues in molecular biology · 2025Article
- A witches' broom phytoplasma effector induces stunting by stabilizing a bHLH transcription factor in Ziziphus jujuba plants.The New phytologist · 2025Article
- Allelic variations in GA20ox3 regulate fruit length and seed germination timing for high-altitude adaptation in Arabidopsis thaliana.Nature communications · 2025Article
- The GRAS protein RAM1 interacts with WRI transcription factors to regulate plant genes required for arbuscule development and function.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-Canonical Inter-Protein Interactions of Key Proteins Belonging to Cytokinin Signaling Pathways.Plants (Basel, Switzerland) · 2025Review
- Green Revolution DELLA Proteins: Functional Analysis and Regulatory Mechanisms.Annual review of plant biology · 2025Review
- Decoding the Dialog Between Plants and Arbuscular Mycorrhizal Fungi: A Molecular Genetic Perspective.Genes · 2025Review
- Plant hormones and membrane transporters: integrating nutrient uptake, ion homeostasis, and stress responses through hormonal cross-talk.Frontiers in plant science · 2025Review
- Identification and expression responses of TCP gene family inFrontiers in plant science · 2025Article
- Evolutionary analysis of DELLA proteins in sweet potato and related species reveals their roles in development and stress responses.Frontiers in plant science · 2025Article
25 more citing papers are in PubMed but not listed here.
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11 authors at 4 institutions in 4 countries.
Nora Marín-de la RosaInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Berta SotilloInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Pal MiskolcziInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).ORCID http://orcid.org/0000-0002-1036-5831
Daniel J GibbsInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Jorge VicenteInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Pilar CarboneroInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Luis Oñate-SánchezInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Michael J HoldsworthInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).ORCID http://orcid.org/0000-0002-3954-9215
Rishikesh BhaleraoInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
David AlabadíInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.) dalabadi@ibmcp.upv.es.ORCID http://orcid.org/0000-0001-8492-6713
Miguel A BlázquezInstituto de Biología Molecular y Celular de Plantas, 46022 Valencia, Spain (N.M.-d.l.R., B.S., D.A., M.A.B.);Department of Forest Genetics and Plant Physiology, Umeå Plant Science Center, Swedish University of Agricultural Sciences, 90187 Umea, Sweden (P.M., R.B.);Division of Plant and Crop Sciences, School of Biosciences, University of Nottingham, Loughborough LE12 5RD, United Kingdom (D.J.G., J.V., M.J.H.);Centro de Biotecnología y Genómica de Plantas, Escuela Técnica Superior de Ingenieros Agrónomos, Universidad Politécnica de Madrid, Campus de Montegancedo, 28223 Pozuelo de Alarcón, Spain (P.C., L.O.-S.); andCollege of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia (R.B.).
Umeå Plant Science Centre · SEUniversity of Nottingham · GBKing Saud University · SASwedish University of Agricultural Sciences · SE
Funding
Biotechnology and Biological Sciences Research Council BB/G010595/1Biotechnology and Biological Sciences Research Council BB/K000144/1Biotechnology and Biological Sciences Research Council BB/M002268/1
Abstract
DELLA proteins are the master negative regulators in gibberellin (GA) signaling acting in the nucleus as transcriptional regulators. The current view of DELLA action indicates that their activity relies on the physical interaction with transcription factors (TFs). Therefore, the identification of TFs through which DELLAs regulate GA responses is key to understanding these responses from a mechanistic point of view. Here, we have determined the TF interactome of the Arabidopsis (Arabidopsis thaliana) DELLA protein GIBBERELLIN INSENSITIVE and screened a collection of conditional TF overexpressors in search of those that alter GA sensitivity. As a result, we have found RELATED TO APETALA2.3, an ethylene-induced TF belonging to the group VII ETHYLENE RESPONSE FACTOR of the APETALA2/ethylene responsive element binding protein superfamily, as a DELLA interactor with physiological relevance in the context of apical hook development. The combination of transactivation assays and chromatin immunoprecipitation indicates that the interaction with GIBBERELLIN INSENSITIVE impairs the activity of RELATED TO APETALA2.3 on the target promoters. This mechanism represents a unique node in the cross regulation between the GA and ethylene signaling pathways controlling differential growth during apical hook development.
Indexed as
ArabidopsisArabidopsis ProteinsBase SequenceDNA PrimersGibberellinsPolymerase Chain ReactionPromoter Regions, GeneticProtein BindingTranscriptional ActivationTranscription FactorsArabidopsis ProteinsDNA PrimersGAI protein, ArabidopsisGibberellinsTranscription Factors
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