SGLT2 inhibitors × adverse events & safety

SynthesisEuropean journal of clinical pharmacology2014

Efficacy and safety of canagliflozin in subjects with type 2 diabetes: systematic review and meta-analysis.

Xu-Ping Yang et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 6,701 people · 2014

Randomised comparison

Lowered hypoglycaemia

−85%−90% to −78%

Bigger than almost all on the map

As reported

RR 0.15, 95% CI 0.10–0.22

Randomised comparison

Raised adverse events & safety

3.8×2.2× to 6.3×

Bigger than 9 in 10 for adverse events & safety

As reported

RR 3.76, 95% CI 2.23–6.35

Randomised comparison

Raised adverse events & safety

3.3× to 7.5×

Bigger than almost all for adverse events & safety

As reported

RR 4.95, 95% CI 3.25–7.52

Three numbers in the abstract

the abstract, start to end

lower than glimepiride (risk ratio (RR) 0.15, 95%CI [0.10 to 0.22]).

with canagliflozin (vs. placebo, RR 3.76, 95%CI [2.23 to 6.35]; vs. active comparators, RR 4.95, 95%CI [3.25 to 7.52]).

← favours treatmentfavours comparator →
could be chance
Hypoglycaemia
RR 0.150.10–0.22
Adverse events & safety
RR 3.762.23–6.35
Adverse events & safety
RR 4.953.25–7.52
SGLT2 inhibitorsSulfonylureas & glinidesAdverse events & safetyHypoglycaemia

SGLT2 inhibitors × adverse events & safetyharms?mixed

unlikelylikely
0.00not counted

Sulfonylureas & glinides × hypoglycaemiaharms?one trial

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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