ReviewMolecular psychiatry2015
An overview of the neurobiology of suicidal behaviors as one meta-system.
Review in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Suicide in neurodegenerative diseases: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia.Molecular psychiatry · 2017Pooled it
- [Nutritional and sedentary habits associated with suicidal behavior in Argentine adolescents: CHAID decision tree]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025Article
- An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Using the stress-vulnerability model to better understand suicide in prison populations.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2023Article
- Association Between Serum Uric Acid Levels and Suicide Attempts in Adolescents and Young Adults with Major Depressive Disorder: A Retrospective Study.Neuropsychiatric disease and treatment · 2022Article
- Demographic profile of patients and risk factors associated with suicidal behaviour in a South African district hospital.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2021Observational
- Gradually evaluating of suicidal risk in depression by semi-supervised cluster analysis on resting-state fMRI.Brain imaging and behavior · 2021Article
- A Brain-Centric Model of Suicidal Behavior.The American journal of psychiatry · 2020Article
- Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study.Molecular psychiatry · 2020Article
- Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation.Journal of autism and developmental disorders · 2020Article
- Suicide in DSM-5: Current Evidence for the Proposed Suicide Behavior Disorder and Other Possible Improvements.Frontiers in psychiatry · 2020Review
- Differentially methylated regions in bipolar disorder and suicide.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Alterations in Gene and Protein Expression of Cannabinoid CBNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Article
- Adolescent substance use behavior and suicidal behavior for boys and girls: a cross-sectional study by latent analysis approach.BMC psychiatry · 2017Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder.Scientific reports · 2017Article
- Polygenic associations of neurodevelopmental genes in suicide attempt.Molecular psychiatry · 2016Article
- Article
- Glutamine Metabolite Ratios are Related to Thwarted Belongingness and Perceived Burdensomeness: Preliminary Evidence from a Veteran Sample with and Without History of Suicidal Ideation.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suicidal behaviors (SB) may be regarded as the outmost consequence of mental illnesses, or as a distinct entity per se. Regardless, the consequences of SB are very large to both society and affected individuals. The path leading to SB is clearly a complex one involving interactions between the subject's biology and environmental influences throughout life. With the aim to generate a representative and diversified overview of the different neurobiological components hypothesized or shown implicated across the entire SB field up to date by any approach, we selected and compiled a list of 212 gene symbols from the literature. An increasing number of novel gene (products) have been introduced as candidates, with half being implicated in SB in only the last 4 years. These candidates represent different neuro systems and functions and might therefore be regarded as competing or redundant explanations. We then adopted a unifying approach by treating them all as parts of the same meta-system, using bioinformatic tools. We present a network of all components connected by physical protein-protein interactions (the SB interactome). We proceeded by exploring the differences between the highly connected core (~30% of the candidate genes) and its peripheral parts, observing more functional homogeneity at the core, with multiple signal transduction pathways and actin-interacting proteins connecting a subset of receptors in nerve cell compartments as well as development/morphology phenotypes and the stress-sensitive synaptic plasticity processes of long term potentiation/depression. We suggest that SB neurobiology might also be viewed as one meta-system and perhaps be explained as intrinsic unbalances acting within the core or as imbalances arising between core and specific peripheral components.
Indexed as
Identifiers
25178164What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.