SynthesisDiabetes2015
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 6 pooled it
3.7field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 6 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.Diabetologia · 2022Pooled it
- Association between type 2 diabetes and amyotrophic lateral sclerosis.Scientific reports · 2022Pooled it
- Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.Diabetologia · 2021Pooled it
- ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.Nature communications · 2019Pooled it
- Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population.Cardiovascular diabetology · 2016Pooled it
- Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach.BioMed research international · 2015Pooled it
- Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.Clinical epigenetics · 2018Trial
- Revealing genetic foundations underlying cardiometabolic traits: integrating twin and GWAS data in Asian populations.International journal of obesity (2005) · 2026Article
- Article
- Relationships between glucose variability with white matter hyperintensity and cerebrovascular abnormalities.Archives of endocrinology and metabolism · 2026Article
- Fasting plasma glucose outperformed 1-hour plasma glucose in predicting diabetes incidence in individuals with family history of young-onset type 2 diabetes.BMJ open diabetes research & care · 2025Article
- Visit-to-visit glucose variability is associated with echocardiographic variables in people with type 2 diabetes: epidemiological and mendelian randomization approaches.Diabetology & metabolic syndrome · 2025Article
- Cohort profile update: the Korean Cancer Prevention Study-II (KCPS-II) biobank.Epidemiology and health · 2025Article
- A comprehensive multi-task deep learning approach for predicting metabolic syndrome with genetic, nutritional, and clinical data.Scientific reports · 2024Article
- Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis.Cancer medicine · 2024Article
- Causal link between metabolic related factors and osteoarthritis: a Mendelian randomization investigation.Frontiers in nutrition · 2024Article
- Whole-exome sequencing reveals novel variants of monogenic diabetes in Tunisia: impact on diagnosis and healthcare management.Frontiers in genetics · 2023Article
- Article
- Genetics of Type 2 Diabetes: Past, Present, and Future.Nutrients · 2022Review
- The Antidiabetic Activities of Neocryptotanshinone: Screened by Molecular Docking and Related to the Modulation of PTP1B.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors at 20 institutions in 7 countries.
Joo-Yeon HwangCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Xueling SimDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC.
Jun LiangDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Cheng HuShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Kazuo HaraDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan.
Claudia H T TamDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Qi ZhaoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Sunha JeeInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Min Jin GoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Rick Twee Hee OngSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Takayoshi OhkuboDepartment of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
Young Jin KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Rong ZhangShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Toshimasa YamauchiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Wing Yee SoDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Dongfeng GuState Key Laboratory of Cardiovascular Disease, Department of Epidemiology, National Center for Cardiovascular Diseases, Beijing, China Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China Peking Union Medical College, Beijing, China.
Nanette R LeeOffice of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
Soriul KimInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
Ji Hee OhCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Satoshi UmemuraDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
Yeon-Jung KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Feng JiangShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Shiro MaedaLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Juliana C N ChanDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
Wei LuShanghai Municipal Center for Disease Control & Prevention, Shanghai, China.
James E HixsonHuman Genetics Center, The University of Texas School of Public Health, Houston, TX.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, NC.
Keum Ji JungInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Toru NabikaDepartment of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
Jae-Bum BaeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Mi Hee LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Mark SeielstadInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA.
Terri L YoungCenter for Human Genetics, Duke University Medical Center, Durham, NC.
Yik Ying TeoCentre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.
Yoshikuni KitaDepartment of Health Science, Shiga University of Medical Science, Shiga, Japan.
Naoyuki TakashimaDepartment of Health Science, Shiga University of Medical Science, Shiga, Japan.
Haruhiko OsawaDepartment of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
So-Hyun LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Dong Hoon ShinDepartment of Occupational and Environmental Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Bo Youl ChoiDepartment of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
Jiajun ShiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Yu-Tang GaoShanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yong-Bing XiangShanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Miwuk YoonInstitute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Xiao Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
Ronald C W MaDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Weiping JiaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Tetsuro MikiDepartment of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
E Shyong TaiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Department of Medicine, National University of Singapore, Singapore, Singapore Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC.
Bok-Ghee HanCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
Bong-Jo KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
Korea National Institute of Health · KRVanderbilt University · USPrince of Wales Hospital · CNShanghai Jiao Tong University · CNShiga University of Medical Science · JPThe University of Tokyo · JPUniversity of North Carolina at Chapel Hill · USEhime University · JPHarvard University · USKorea Health Promotion Institute · KRNational Center for Global Health and Medicine · JPNational University of Singapore · SGShanghai Sixth People's Hospital · CNTulane University · USYonsei University · KRAgency for Science, Technology and Research · SGChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese University of Hong Kong · HKChonnam National University Hospital · KRDuke University Hospital · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MGenetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MCohort Study of Cancer inhibitory Factors in MenR01CA082729 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2011
$6.3MGENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MShanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9MShanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8MFIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288FIC NIH HHS TW008288FIC NIH HHS TW05596Intramural NIH HHS Z01 HG000024NCI NIH HHS R01 CA064277NCI NIH HHS R01CA064277NCI NIH HHS R01 CA082729NCI NIH HHS R01CA082729NCI NIH HHS R01 CA122364NCI NIH HHS R01CA122364NCI NIH HHS R01 CA122756NCI NIH HHS R01CA122756NCI NIH HHS R01 CA124558NCI NIH HHS R01CA124558NCI NIH HHS R01 CA137013NCI NIH HHS R01CA137013NCI NIH HHS R01 CA148667NCI NIH HHS R01CA148667NCI NIH HHS R37 CA070867NCI NIH HHS R37CA070867NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NCRR NIH HHS P20 RR020649NCRR NIH HHS RR20649NHGRI NIH HHS 1Z01 HG000024NHLBI NIH HHS HL085144NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01HL090682NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01HL072507NIDDK NIH HHS DK062370NIDDK NIH HHS DK072193NIDDK NIH HHS DK078150NIDDK NIH HHS DK-085545-01NIDDK NIH HHS DK093757NIDDK NIH HHS DK56350NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R56 DK062370NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK085545NIEHS NIH HHS ES10126NIEHS NIH HHS P30 ES010126
Abstract
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.
Indexed as
Genome-Wide Association StudyAdaptor Proteins, Signal TransducingAdultAgedAsia, EasternAsian PeopleBlood GlucoseCytoskeletal ProteinsFastingFemaleGenetic VariationGenotypeGuanine Nucleotide Exchange FactorsHumansMaleMiddle AgedAdaptor Proteins, Signal TransducingBlood GlucoseCytoskeletal ProteinsGuanine Nucleotide Exchange FactorsKANK1 protein, humanPDK1 protein, humanProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseRAPGEF4 protein, humanReceptor, IGF Type 1Tumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.