Evidence map›Paper›PMID 25201890›Full record

ArticleHypertension (Dallas, Tex. : 1979)2014

Elimination of vitamin D receptor in vascular endothelial cells alters vascular function.

Wei Ni, Stephanie W Watts, Michael Ng, Songcang Chen, Denis J Glenn, David G Gardner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 162 citations in OpenAlex.

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  16. Vitamin D deficiency promotes intracranial aneurysm rupture.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei NiFrom the Department of Medicine and Diabetes Center, University of California at San Francisco (W.N., M.N., S.C., D.J.G. and D.G.G); and the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (S.W.W.). niwei78@gmail.com.
Stephanie W WattsFrom the Department of Medicine and Diabetes Center, University of California at San Francisco (W.N., M.N., S.C., D.J.G. and D.G.G); and the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (S.W.W.).
Michael NgFrom the Department of Medicine and Diabetes Center, University of California at San Francisco (W.N., M.N., S.C., D.J.G. and D.G.G); and the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (S.W.W.).
Songcang ChenFrom the Department of Medicine and Diabetes Center, University of California at San Francisco (W.N., M.N., S.C., D.J.G. and D.G.G); and the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (S.W.W.).
Denis J GlennFrom the Department of Medicine and Diabetes Center, University of California at San Francisco (W.N., M.N., S.C., D.J.G. and D.G.G); and the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (S.W.W.).
David G GardnerFrom the Department of Medicine and Diabetes Center, University of California at San Francisco (W.N., M.N., S.C., D.J.G. and D.G.G); and the Department of Pharmacology and Toxicology, Michigan State University, East Lansing (S.W.W.).
Michigan State University · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
REGULATION OF ANP RECEPTOR ACTIVITY IN VASCULAR CELLSR01HL045637 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARDNER, DAVID G · 1992 to 2011
$3.6M
DGAT1 Mediated Cardiac SteatosisK08HL095735 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLENN, DENIS J · 2009 to 2013
$625k
Characterization of the Vitamin D System in Normal and Hypertrophied HeartF32HL086158 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLENN, DENIS J · 2006 to 2008
$110k
NHLBI NIH HHS F32 HL086158NHLBI NIH HHS HL45637NHLBI NIH HHS K08 HL086158NHLBI NIH HHS K08 HL095735NHLBI NIH HHS R01 HL045637NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Vitamin D deficiency has been associated with cardiovascular dysfunction. We evaluated the role of the vitamin D receptor (VDR) in vascular endothelial function, a marker of cardiovascular health, at baseline and in the presence of angiotensin II, using an endothelial-specific knockout of the murine VDR gene. In the absence of endothelial VDR, acetylcholine-induced aortic relaxation was significantly impaired (maximal relaxation, endothelial-specific VDR knockout=58% versus control=73%; P<0.05). This was accompanied by a reduction in endothelial NO synthase expression and phospho-vasodilator-stimulated phosphoprotein levels in aortae from the endothelial-specific VDR knockout versus control mice. Although blood pressure levels at baseline were comparable at 12 and 24 weeks of age, the endothelial VDR knockout mice demonstrated increased sensitivity to the hypertensive effects of angiotensin II compared with control mice (after 1-week infusion: knockout=155±15 mm Hg versus control=133±7 mm Hg; P<0.01; after 2-week infusion: knockout=164±9 mm Hg versus control=152±13 mm Hg; P<0.05). By the end of 2 weeks, angiotensin II infusion-induced, hypertrophy-sensitive myocardial gene expression was higher in endothelial-specific VDR knockout mice (fold change compared with saline-infused control mice, type-A natriuretic peptide: knockout mice=3.12 versus control=1.7; P<0.05; type-B natriuretic peptide: knockout mice=4.72 versus control=2.68; P<0.05). These results suggest that endothelial VDR plays an important role in endothelial cell function and blood pressure control and imply a potential role for VDR agonists in the management of cardiovascular disease associated with endothelial dysfunction.

Indexed as

AcetylcholineAngiotensin IIAnimalsAortaBlood PressureBlotting, WesternDisease Models, AnimalDNAEndothelial CellsEndothelium, VascularGene Expression RegulationHumansHypertensionImmunohistochemistryMaleMiceAcetylcholineAngiotensin IIDNANatriuretic Peptide, BrainReceptors, Calcitriolgene targetinghypertensionreceptors, calcitriolvitamin D

Identifiers

PMID25201890
PMCPMC4430199
OpenAlexW1976312420

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.