ArticleVascular health and risk management2014
Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women.
Article in Vascular health and risk management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Prognostic significance of stress hyperglycemia ratio in coronary microvascular dysfunction among chronic coronary syndrome patients.Frontiers in cardiovascular medicine · 2026Article
- Association between bone mineral density and vascular health in rheumatoid arthritis.Singapore medical journal · 2025Article
- Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies.Frontiers in cardiovascular medicine · 2025Review
- The associations of markers of endothelial dysfunction with hip fracture risk.Archives of osteoporosis · 2023Article
- Coronary microvascular dysfunction is an independent predictor of developing cancer in patients with non-obstructive coronary artery disease.European journal of preventive cardiology · 2023Article
- The Association of Coronary Artery Calcium Score and Osteoporosis in Postmenopausal Women: A Cross-Sectional Study.Journal of bone metabolism · 2022Article
- Atherosclerosis and multi-organ-associated pathologies.Seminars in immunopathology · 2022Review
- Bifurcation functional significance score as predictor of mortality: a validating study.Scientific reports · 2021Observational
- Genetic Scores ofInternational journal of environmental research and public health · 2021Article
- Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart.Cardiovascular research · 2021Review
- The association between CD31Journal of bone and mineral metabolism · 2019Article
- Triglyceride and Triglyceride/ HDL (High Density Lipoprotein) Ratio Predict Major Adverse Cardiovascular Outcomes in Women With Non-Obstructive Coronary Artery Disease.Journal of the American Heart Association · 2019Article
- The role of vasculature in bone development, regeneration and proper systemic functioning.Angiogenesis · 2017Review
- Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axis.Scientific reports · 2017Article
- Uric Acid Is Associated With Inflammation, Coronary Microvascular Dysfunction, and Adverse Outcomes in Postmenopausal Women.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Correlation between physical activity and cardiovascular risk factors in postmenopausal women from Colombia Caribbean.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA growing body of evidence links coronary artery atherosclerosis and calcification to osteoporosis in women. The endothelium plays a critical role in maintaining vascular integrity and may play a role in bone metabolism. We aimed to determine whether early coronary atherosclerosis, as detected by coronary microvascular endothelial dysfunction (CMED), predicts the development of osteoporosis in postmenopausal women.
methodsCoronary vascular reactivity was evaluated in 194 postmenopausal women greater than 50 years of age and with non-obstructive coronary arteries by administration of intracoronary acetylcholine during diagnostic angiography. CMED was defined as ≤50% increase in coronary blood flow from baseline in response to maximal dose. After a median follow-up of 7.0±0.3 years, patients were assessed by a questionnaire for development of osteoporosis.
resultsThe average age of the cohort was 60.9±7.4 years. Women with CMED were twice as likely to develop osteoporosis compared with women without endothelial dysfunction after adjustment for potential confounders (relative risk, 2.4; 95% confidence interval [CI], 1.1, 5.6, P=0.02). Epicardial endothelial dysfunction was not associated with development of osteoporosis. DISCUSSION: Early coronary atherosclerosis with endothelial dysfunction is an independent marker for increased risk of developing osteoporosis in postmenopausal women greater than 50 years of age without obstructive coronary artery disease. The current study supports a link between coronary atherosclerosis and osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.