Evidence mapPaperPMID 25216871Full record

ArticleThe international journal of cardiovascular imaging2015

Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study.

Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Daniel S Hippe, Thomas S Hatsukami, Daniel A Isquith, Kiyofumi Yamada, Moni B Neradilek, Gádor Cantón, Yunjing Xue and 7 more

Registry-linked trialAbstract readComparative StudyEvaluation StudyMulticenter Study
In one paragraph

Article in The international journal of cardiovascular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01178320. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01178320 completed

Carotid Plaque Characteristics by MRI in AIM-HIGH

Ran2008Enrolled230Registered outcomes2Posted comparisons0ConditionsAtherosclerosis, Carotid Artery Diseases, Coronary Artery DiseaseArmsSimvastatin, simvastatin plus extended-release niacin
PMID 25084698PMID 29301785PMID 25245415other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  15. Cardiovascular risk assessment: The foundation of preventive cardiology.American journal of preventive cardiology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Jie SunDepartment of Radiology, University of Washington, 850 Republican St Brotman 127, Seattle, WA, 98109, USA, sunjie@u.washington.edu.
Xue-Qiao Zhao
Niranjan Balu
Daniel S Hippe
Thomas S Hatsukami
Daniel A Isquith
Kiyofumi Yamada
Moni B Neradilek
Gádor Cantón
Yunjing Xue
Jerome L Fleg
Patrice Desvigne-Nickens
Michael T Klimas
Robert J Padley
Maria T Vassileva
Bradley T Wyman
Chun Yuan
University of Washington · USNational Institutes of Health · USAbbVie (United States) · USFoundation for the National Institutes of Health · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPfizer (United States) · USThe Mountain Institute · US

Funding

NHLBI NIH HHS R01 HL088214NHLBI NIH HHS R01HL088214
6 · The paper itself

Abstract

This study sought to determine the multicenter reproducibility of magnetic resonance imaging (MRI) and the compatibility of different scanner platforms in assessing carotid plaque morphology and composition. A standardized multi-contrast MRI protocol was implemented at 16 imaging sites (GE: 8; Philips: 8). Sixty-eight subjects (61 ± 8 years; 52 males) were dispersedly recruited and scanned twice within 2 weeks on the same magnet. Images were reviewed centrally using a streamlined semiautomatic approach. Quantitative volumetric measurements on plaque morphology (lumen, wall, and outer wall) and plaque tissue composition [lipid-rich necrotic core (LRNC), calcification, and fibrous tissue] were obtained. Inter-scan reproducibility was summarized using the within-subject standard deviation, coefficient of variation (CV) and intraclass correlation coefficient (ICC). Good to excellent reproducibility was observed for both morphological (ICC range 0.98-0.99) and compositional (ICC range 0.88-0.96) measurements. Measurement precision was related to the size of structures (CV range 2.5-4.9 % for morphology, 36-44 % for LRNC and calcification). Comparable measurement variability was found between the two platforms on both plaque morphology and tissue composition. In conclusion, good to excellent inter-scan reproducibility of carotid MRI can be achieved in multicenter settings with comparable measurement precision between platforms, which may facilitate future multicenter endeavors that use serial MRI to monitor atherosclerotic plaque progression.

Indexed as

Magnetic Resonance AngiographyPlaque, AtheroscleroticAgedAged, 80 and overCanadaCarotid ArteriesCarotid Artery DiseasesChinaDisease ProgressionEquipment DesignFeasibility StudiesFemaleFibrosisHumansImage Interpretation, Computer-AssistedLipidsLipids

Identifiers

PMID25216871
PMCPMC4297722
OpenAlexW2158564618

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.