Evidence map›Paper›PMID 25229259›Full record

ReviewCurrent opinion in gastroenterology2014

Gastroduodenal mucosal defense.

Thomas Kemmerly, Jonathan D Kaunitz

Abstract readReview
In one paragraph

Review in Current opinion in gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas KemmerlyaCedars-Sinai Medical Residency Program bGreater Los Angeles Veteran Affairs Healthcare System, WLAVA Medical Center cDepartments of Medicine and Surgery, UCLA School of Medicine dDepartment of Medicine, CURE: Digestive Diseases Research Center eBrentwood Biomedical Research Institute, Los Angeles, California, USA.
Jonathan D Kaunitz

Funding

Duodenal Muscosal Defense MechanismsR01DK054221 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAUNITZ, JONATHAN D. · 1999 to 2016
$4.4M
BLRD VA I01 BX001245NIDDK NIH HHS R01 DK054221
6 · The paper itself

Abstract

purpose of reviewTo review recent developments in the field of gastroduodenal mucosal defense. RECENT

findingsResearch in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals that familiar proteins and mediators, such as nitric oxide, toll-like receptors, nucleotide-binding oligomerization domain-containing proteins (NOD2), β-defensins, macrophages, dendritic cells, mucins, autophagy, and the influence of aging and diet, are still subjects of study, but also brings into light new processes and mediators, such as dual oxidases, defense against radiation injuries, and novel proteins such as ZBP-89. SUMMARY: These new published findings contribute to our overall understanding of gastroduodenal defense and suggest innovative avenues of future research and possible novel therapeutic targets.

Indexed as

Apoptosisbeta-DefensinsCell CommunicationDuodenumGastric MucosaGastrointestinal DiseasesHumansImmunity, InnateMucinsNitric OxideOxidative StressToll-Like Receptor 5beta-DefensinsMucinsNitric OxideTLR5 protein, humanToll-Like Receptor 5

Identifiers

PMID25229259
PMCPMC4238382

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.