ArticleMagnetic resonance in medicine2015
Increased SNR efficiency in velocity selective arterial spin labeling using multiple velocity selective saturation modules (mm-VSASL).
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Velocity Spectrum Imaging Using Velocity Encoding Preparation Pulses.Magnetic resonance in medicine · 2026Article
- Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post-labeling delays: The effect of fast flow.Magnetic resonance in medicine · 2024Article
- Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.Magnetic resonance in medicine · 2024Review
- Optimizing background suppression for dual-module velocity-selective arterial spin labeling: Without using additional background-suppression pulses.Magnetic resonance in medicine · 2024Article
- ASL lexicon and reporting recommendations: A consensus report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI).Magnetic resonance in medicine · 2024Article
- Evaluation of 3D stack-of-spiral turbo FLASH acquisitions for pseudo-continuous and velocity-selective ASL-derived brain perfusion mapping.Magnetic resonance in medicine · 2023Article
- Robust dual-module velocity-selective arterial spin labeling (dm-VSASL) with velocity-selective saturation and inversion.Magnetic resonance in medicine · 2023Article
- Velocity-selective excitation: Principles and applications.NMR in biomedicine · 2023Review
- Velocity-selective arterial spin labeling perfusion MRI: A review of the state of the art and recommendations for clinical implementation.Magnetic resonance in medicine · 2022Review
- Exploring label dynamics of velocity-selective arterial spin labeling in the kidney.Magnetic resonance in medicine · 2021Article
- Spatial dependency and the role of local susceptibility for velocity selective arterial spin labeling (VS-ASL) relative tagging efficiency using accelerated 3D radial sampling with a BIR-8 preparation.Magnetic resonance in medicine · 2021Article
- Multi-organ comparison of flow-based arterial spin labeling techniques: Spatially non-selective labeling for cerebral and renal perfusion imaging.Magnetic resonance in medicine · 2021Article
- Comparison of velocity-selective arterial spin labeling schemes.Magnetic resonance in medicine · 2021Article
- Breath-Hold Induced Cerebrovascular Reactivity Measurements Using Optimized Pseudocontinuous Arterial Spin Labeling.Frontiers in physiology · 2021Article
- Improved velocity-selective-inversion arterial spin labeling for cerebral blood flow mapping with 3D acquisition.Magnetic resonance in medicine · 2020Article
- PredictingJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.Magnetic resonance in medicine · 2018Review
- Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Arterial spin labeling for the measurement of cerebral perfusion and angiography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeVelocity-selective arterial spin labeling (VSASL) is theoretically insensitive to transit delay (TD) effects. However, it uses saturation instead of inversion, resulting in compromised signal to noise ratio (SNR). In this study we explore the use of multiple velocity-selective saturation (VSS) modules in VSASL (mm-VSASL) to improve SNR.
methodsTheoretical SNR efficiency improvement and optimized parameters were calculated from simulations for mm-VSASL. VSASL with two VSS modules (VSASL-2VSS) was implemented to measure cerebral blood flow in vivo, compared with conventional VSASL (VSASL-1VSS), pulsed ASL (PASL), and pseudo-continuous ASL (PCASL). TDs and bolus durations (BDs) were measured to validate the simulations and to examine the TD sensitivity of these preparations.
resultsCompared with VSASL-1VSS, VSASL-2VSS achieved a significant improvement of SNR (22.1 ± 1.9%, P = 1.7 × 10(-6) ) in vivo, consistent with a 22.7% improvement predicted from simulations. The SNR was comparable to or higher (in gray matter, P = 4.3 × 10(-3) ) than that using PCASL. VSASL was experimentally verified to have minimal TD effects.
conclusionUtilizing multiple VSS modules can improve the SNR efficiency of VSASL. Mm-VSASL may result in an SNR that is comparable to or even higher than that of PCASL in applications where long postlabeling delays are required.
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