SynthesisPloS one2014
The effect of periodontal treatment on hemoglobin a1c levels of diabetic patients: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Combined Non-surgical and Surgical Periodontal Treatment in Patients With Type 2 Diabetes Mellitus
Evaluation of Periodontal Clinical Parameters and Blood Tests in Diabetic Patients Submitted to Non-surgical Periodontal Treatment
Who cites it
33 citing papers in PubMed, 8 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- An umbrella review of systematic reviews examining the relationship between type 2 diabetes and periodontitis: Position paper from the Canadian Dental Hygienists Association.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Systemic doxycycline as an adjunct to scaling and root planing in diabetic patients with periodontitis: a systematic review and meta-analysis.BMC oral health · 2019Pooled it
- Effect of non-surgical periodontal therapy on glycemic control of type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis.BMC oral health · 2019Pooled it
- Oral health knowledge, attitudes and care practices of people with diabetes: a systematic review.BMC public health · 2018Pooled it
- Evaluation of Recombinant Human FGF-2 and PDGF-BB in Periodontal Regeneration: A Systematic Review and Meta-Analysis.Scientific reports · 2017Pooled it
- Systematic review and assessment of systematic reviews examining the effect of periodontal treatment on glycemic control in patients with diabetes.Medicina oral, patologia oral y cirugia bucal · 2017Pooled it
- The effect of periodontal therapy on glycemic control and fasting plasma glucose level in type 2 diabetic patients: systematic review and meta-analysis.BMC oral health · 2016Pooled it
- Periodontitis treatment (surgical and nonsurgical) effects on glycemic control: A review and meta-analysis.Annals of African medicinePooled it
- Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial.International journal of cardiology · 2018Trial
- Trial
- Association Between Oral Health and Metabolic Dysfunction-Associated Steatotic Liver Disease Among US Adults.Clinical and translational gastroenterology · 2026Article
- Periodontitis and Systemic Health: An Interconnected Relationship.Advances in experimental medicine and biology · 2026Review
- Oral Health of Children and Adolescents with Diabetes Mellitus.Journal of clinical medicine · 2024Article
- More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024Review
- Changes in masticatory performance and the new onset of diabetes mellitus in older adults: a 5-year longitudinal study.Diabetology international · 2023Article
- Current scientific evidence for why periodontitis should be included in diabetes management.Frontiers in clinical diabetes and healthcare · 2023Article
- Association between Periodontitis and Diabetes Mellitus in the General Population.Journal of diabetes and metabolic disorders · 2022Article
- Accuracy of a 7-Item Patient-Reported Stand-Alone Tool for Periodontitis Screening.Journal of clinical medicine · 2021Article
- Impact of Liability to Periodontitis on Glycemic Control and Type II Diabetes Risk: A Mendelian Randomization Study.Frontiers in genetics · 2021Article
- Inflammation and Vascular Ageing: From Telomeres to Novel Emerging Mechanisms.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence that periodontal treatment may affect glycemic control in diabetic patients. And several systematic reviews have been conducted to assess the effect of periodontal treatment on diabetes outcomes. Researches of this aspect are widely concerned, and several new controlled trials have been published. The aim of this study was to update the account for recent findings.
methodsA literature search (until the end of January 2014) was carried out using various databases with language restriction to English. A randomized controlled trial (RCT) was selected if it investigated periodontal therapy for diabetic subjects compared with a control group received no periodontal treatment for at least 3 months of the follow-up period. The primary outcome was hemoglobin A1c (HbA1c), and secondary outcomes were periodontal parameters included probing pocket depth (PPD) and clinical attachment level (CAL).
resultsTen trials of 1135 patients were included in the analysis. After the follow-up of 3 months, treatment substantially lowered HbA1c compared with no treatment after periodontal therapy (-0.36%, 95%CI, -0.52% to -0.19%, P<0.0001). Clinically substantial and statistically significant reduction of PPD and CAL were found between subjects with and without treatment after periodontal therapy (PPD -0.42 mm, 95%CI: -0.60 to -0.23, P<0.00001; CAL -0.34 mm, 95%CI: -0.52 to -0.16, P=0.0002). And there is no significant change of the level of HbA1c at the 6-month comparing with no treatment (-0.30%, 95%CI, -0.69% to 0.09%, P=0.13).
conclusionsPeriodontal treatment leads to the modest reduction in HbA1c along with the improvement of periodontal status in diabetic patients for 3 months, and this result is consistent with previous systematic reviews. And the effect of periodontal treatment on HbA1c cannot be observed at 6-month after treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.