Metformin × cardiovascular events

SynthesisBMC cardiovascular disorders2014

The risk of heart failure associated with the use of noninsulin blood glucose-lowering drugs: systematic review and meta-analysis of published observational studies.

Cristina Varas-Lorenzo et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 4 people · 2014

Randomised comparison

Probably increased cardiovascular events

2.2×1.4× to 3.5×

Bigger than 9 in 10 for cardiovascular events

As reported

RR 2.23, 95% CI 1.41–3.53

Not counted

Probably increased cardiovascular events

+22%+2% to +46%

Bigger than 4 in 10 for cardiovascular events

As reported

RR 1.22, 95% CI 1.02–1.46

Range includes no effect

No clear effect on cardiovascular events

+22%−14% to +74%

Bigger than 4 in 10 for cardiovascular events

As reported

RR 1.22, 95% CI 0.86–1.74

Range includes no effect

No clear effect on cardiovascular events

+14%−14% to +50%

Bigger than 2 in 10 for cardiovascular events

As reported

RR 1.14, 95% CI 0.86–1.50

+3 more in the walkthrough ↓

Seven numbers in the abstract

the abstract, start to end

yielding a summary relative risk of 1.22 (95% CI, 1.02-1.46) (Table 3

users reported a relative risk of 1.22 (95% CI, 0.86-1.74) [36].

yielding a summary relative risk of 1.14 (95% CI, 0.86-1.50); we

agents, versus metformin was 1.36 (95% CI, 1.17-1.59) [36, 40,

those using lower doses (hazard ratio, 1.38; 95% CI, 1.20-1.60) [41].

users of pioglitazone (relative risk, 1.21; 95% CI, 1.03-1.42), and

by Loebstein et al. [40] (relative risk, 2.23; 95% CI, 1.41-3.53) might be

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 1.221.02–1.46
Cardiovascular events
RR 1.220.86–1.74
Cardiovascular events
RR 1.140.86–1.50
Glycemic control
−1.36−1.59 to −1.17
Cardiovascular events
HR 1.381.20–1.60
Adverse events & safety
RR 1.211.03–1.42
Cardiovascular events
RR 2.231.41–3.53
MetforminSulfonylureas & glinidesThiazolidinedionesOther glucose-loweringGlycemic controlCardiovascular eventsAdverse events & safety

Metformin × cardiovascular eventshelps?mixed

unlikelylikely
0.50not counted

Sulfonylureas & glinides × cardiovascular eventshelps?replicated

unlikelylikely
0.96not counted

Thiazolidinediones × cardiovascular eventshelps?mixed

unlikelylikely
0.00not counted
← favours treatmentfavours comparator →
more certainless certain
1 / 6

25 papers cite it

2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
this paperpooled ittrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 25260374