SynthesisInternational journal of molecular sciences2014
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
Synthesis in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- CDKN2B-AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta-analysis of 40,979 subjects.Journal of cellular and molecular medicine · 2021Pooled it
- Association of ANRIL polymorphisms with coronary artery disease: A systemic meta-analysis.Medicine · 2020Pooled it
- Rs10757274 gene polymorphisms in coronary artery disease: A systematic review and a meta-analysis.Medicine · 2020Pooled it
- Pooled it
- Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis.Bioscience reports · 2018Pooled it
- Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar.Molecular genetics & genomic medicine · 2023Article
- The Link betweenBioMed research international · 2022Article
- Regulation of Long Non-Coding RNAs by Statins in Atherosclerosis.Biomolecules · 2021Review
- New findings in the roles of Cyclin-dependent Kinase inhibitors 2B Antisense RNA 1 (Bioengineered · 2020Article
- Long non-coding RNA CDKN2B-AS1 contributes to atherosclerotic plaque formation by forming RNA-DNA triplex in the CDKN2B promoter.EBioMedicine · 2020Article
- The association between the chromosome 9p21 CDKN2B-AS1 gene variants and the lipid metabolism: A pre-diagnostic biomarker for coronary artery disease.Anatolian journal of cardiology · 2019Article
- Association of theJournal of cardiovascular and thoracic research · 2019Article
- Association of BAX hypermethylation with coronary heart disease is specific to individuals aged over 70.Medicine · 2019Article
- Association of polymorphisms in MALAT1 with risk of coronary atherosclerotic heart disease in a Chinese population.Lipids in health and disease · 2018Article
- Association of expression ofJournal of pain research · 2018Article
- Impact of gender and age on the association of the BUD13-ZNF259 rs964184 polymorphism with coronary heart disease.Anatolian journal of cardiology · 2018Article
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- Chemotherapy-induced hypomethylation of N-myc downstream-regulated gene 4 in the bone marrow of patients with acute myeloid leukemia.Oncology letters · 2017Article
- Association ofClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of our study was to explore the significant association between a non-protein coding single nucleotide polymorphism (SNP) rs4977574 of CDKN2BAS gene and coronary heart disease (CHD). A total of 590 CHD cases and 482 non-CHD controls were involved in the present association study. A strong association of rs4977574 with CHD was observed in females (genotype: p=0.002; allele: p=0.002, odd ratio (OR)=1.57, 95% confidential interval (CI)=1.18-2.08). Moreover, rs4977574 was more likely to be a risk variant of CHD under the recessive model in females (χ2=10.29, p=0.003, OR=2.14, 95% CI=1.31-2.77). A breakdown analysis by age had shown that there was an 87% increased risk of CHD for females younger than 65 years (genotype: χ2=14.64, degrees of freedom (df)=2, p=0.0002; allele: χ2=11.31, df=1, p=0.0008, OR=1.87, 95% CI=1.30-2.70). Similar observation was also found in males younger than 65 years (genotype: χ2=8.63, df=2, p=0.04; allele: χ2=7.55, df=1, p=0.006, OR=1.45, 95% CI=1.11-1.90). p values were adjusted by age, sex, smoking, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Meta-analysis of 23 studies among 36,452 cases and 39,781 controls showed a strong association between rs4977574 and the risk of CHD (p<0.0001, OR=1.27, 95% CI=1.22-1.31).
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