ArticleThe Journal of cell biology2014
The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Molecular basis for the calcium-dependent activation of the ribonuclease EndoU.Nature communications · 2025Article
- Article
- The Upstream 1350~1250 Nucleotide Sequences of the HumanInternational journal of molecular sciences · 2023Article
- The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation.Developmental cell · 2023Article
- The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging.Nature communications · 2023Article
- Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans.Nature communications · 2023Article
- Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2022Article
- Poly(U)-specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element-mediated inhibition.The EMBO journal · 2021Article
- The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans.Nature communications · 2021Article
- An ancient evolutionary connection between Ribonuclease A and EndoU families.RNA (New York, N.Y.) · 2020Article
- Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.Cells · 2020Article
- Genome-wide analysis identifiesRNA (New York, N.Y.) · 2020Article
- Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease.Cell reports · 2020Article
- Chromatolysis: Do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA?Developmental neurobiology · 2018Review
- Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- The RNA-binding complex ESCRT-II inThe Journal of biological chemistry · 2018Article
- Functional plasticity of antibacterial EndoU toxins.Molecular microbiology · 2018Article
- Embryonic expression patterns of Eukaryotic EndoU ribonuclease family gene endouC in zebrafish.Gene expression patterns : GEP · 2017Article
- Novel Ribonuclease Activity Differs between Fibrillarins fromFrontiers in plant science · 2017Article
- The endoplasmic reticulum: structure, function and response to cellular signaling.Cellular and molecular life sciences : CMLS · 2016Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How cells shape and remodel organelles in response to cellular signals is a poorly understood process. Using Xenopus laevis egg extract, we found that increases in cytosolic calcium lead to the activation of an endogenous ribonuclease, XendoU. A fraction of XendoU localizes to the endoplasmic reticulum (ER) and is required for nuclear envelope assembly and ER network formation in a catalysis-dependent manner. Using a purified vesicle fusion assay, we show that XendoU functions on the surface of ER membranes to promote RNA cleavage and ribonucleoprotein (RNP) removal. Additionally, RNA removal from the surface of vesicles by RNase treatment leads to increased ER network formation. Using human tissue culture cells, we found that hEndoU localizes to the ER, where it promotes the formation of ER tubules in a catalysis-dependent manner. Together, these results demonstrate that calcium-activated removal of RNA from membranes by XendoU promotes and refines ER remodeling and the formation of tubular ER.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.