ArticleThe Journal of biological chemistry2014
Interaction between the pentose phosphate pathway and gluconeogenesis from glycerol in the liver.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging
Open the trial in the graphEffect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Glycerol Kinase 2 as a Metabolic Sentinel for Human Sperm Motility and Male Fertility.Biomolecules · 2025Review
- Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver.Metabolism: clinical and experimental · 2025Article
- Magnetic Resonance Applications to Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Analysis ofFoods (Basel, Switzerland) · 2023Article
- Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism.Metabolites · 2022Article
- Grape-Seed Procyanidin Extract (GSPE) Seasonal-Dependent Modulation of Glucose and Lipid Metabolism in the Liver of Healthy F344 Rats.Biomolecules · 2022Article
- Comparative transcriptomics reveal tissue level specialization towards diet in prickleback fishes.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep.Metabolites · 2021Article
- Divergent effects of glutathione depletion on isocitrate dehydrogenase 1 and the pentose phosphate pathway in hamster liver.Physiological reports · 2020Article
- Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- Assessing the pentose phosphate pathway using [2, 3-NMR in biomedicine · 2019Article
- Fatty liver disrupts glycerol metabolism in gluconeogenic and lipogenic pathways in humans.Journal of lipid research · 2018Article
- Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver.American journal of physiology. Endocrinology and metabolism · 2018Article
- Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream.Scientific reports · 2018Article
- Effects of visceral adiposity on glycerol pathways in gluconeogenesis.Metabolism: clinical and experimental · 2017Article
- An Oral Load of [13C3]Glycerol and Blood NMR Analysis Detect Fatty Acid Esterification, Pentose Phosphate Pathway, and Glycerol Metabolism through the Tricarboxylic Acid Cycle in Human Liver.The Journal of biological chemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
After exposure to [U-(13)C3]glycerol, the liver produces primarily [1,2,3-(13)C3]- and [4,5,6-(13)C3]glucose in equal proportions through gluconeogenesis from the level of trioses. Other (13)C-labeling patterns occur as a consequence of alternative pathways for glucose production. The pentose phosphate pathway (PPP), metabolism in the citric acid cycle, incomplete equilibration by triose phosphate isomerase, or the transaldolase reaction all interact to produce complex (13)C-labeling patterns in exported glucose. Here, we investigated (13)C labeling in plasma glucose in rats given [U-(13)C3]glycerol under various nutritional conditions. Blood was drawn at multiple time points to extract glucose for NMR analysis. Because the transaldolase reaction and incomplete equilibrium by triose phosphate isomerase cannot break a (13)C-(13)C bond within the trioses contributing to glucose, the appearance of [1,2-(13)C2]-, [2,3-(13)C2]-, [5,6-(13)C2]-, and [4,5-(13)C2]glucose provides direct evidence for metabolism of glycerol in the citric acid cycle or the PPP but not an influence of either triose phosphate isomerase or the transaldolase reaction. In all animals, [1,2-(13)C2]glucose/[2,3-(13)C2]glucose was significantly greater than [5,6-(13)C2]glucose/[4,5-(13)C2]glucose, a relationship that can only arise from gluconeogenesis followed by passage of substrates through the PPP. In summary, the hepatic PPP in vivo can be detected by (13)C distribution in blood glucose after [U-(13)C3]glycerol administration.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.