ArticlePlant physiology2014
Disruption of the CYTOCHROME C OXIDASE DEFICIENT1 gene leads to cytochrome c oxidase depletion and reorchestrated respiratory metabolism in Arabidopsis.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 89 citations in OpenAlex.
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- The role of alternative oxidase in the maintenance of cellular redox balance under hypoxia via participation in nitric oxide turnover.Journal of experimental botany · 2025Review
- Cytochrome c oxidase inactivation in Physcomitrium patens reveals that respiration coordinates plant metabolism.The Plant cell · 2025Article
- Map-based cloning of Zmccr3 and its network construction and validation for regulating maize seed germination.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Assembly and analysis of stephania japonica mitochondrial genome provides new insights into its identification and energy metabolism.BMC genomics · 2025Article
- Multiple factors interact in editing of PPR-E+-targeted sites in maize mitochondria and plastids.Plant communications · 2024Article
- Invited Review Beyond parasitic convergence: unravelling the evolution of the organellar genomes in holoparasites.Annals of botany · 2023Review
- The biogenesis and regulation of the plant oxidative phosphorylation system.Plant physiology · 2023Review
- Responses of the tree peony (Paeonia suffruticosa, Paeoniaceae) cultivar 'Yu Hong' to heat stress revealed by iTRAQ-based quantitative proteomics.Proteome science · 2022Article
- Triticale doubled haploid plant regeneration factors linked by structural equation modeling.Journal of applied genetics · 2022Article
- Mitochondrial HSC70-1 Regulates Polar Auxin Transport through ROS Homeostasis in Arabidopsis Roots.Antioxidants (Basel, Switzerland) · 2022Article
- Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7.The Plant cell · 2022Article
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- Cytonuclear coevolution in a holoparasitic plant with highly disparate organellar genomes.Plant molecular biology · 2022Article
- The P-type pentatricopeptide repeat protein DWEORG1 is a non-previously reported rPPR protein of Arabidopsis mitochondria.Scientific reports · 2022Article
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- Multi-Omics Analysis Reveals the Mechanism Underlying the Edaphic Adaptation in Wild Barley at Evolution Slope (Tabigha).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome c oxidase is the last respiratory complex of the electron transfer chain in mitochondria and is responsible for transferring electrons to oxygen, the final acceptor, in the classical respiratory pathway. The essentiality of this step makes it that depletion in complex IV leads to lethality, thereby impeding studies on complex IV assembly and respiration plasticity in plants. Here, we characterized Arabidopsis (Arabidopsis thaliana) embryo-lethal mutant lines impaired in the expression of the CYTOCHROME C OXIDASE DEFICIENT1 (COD1) gene, which encodes a mitochondria-localized PentatricoPeptide Repeat protein. Although unable to germinate under usual conditions, cod1 homozygous embryos could be rescued from immature seeds and developed in vitro into slow-growing bush-like plantlets devoid of a root system. cod1 mutants were defective in C-to-U editing events in cytochrome oxidase subunit2 and NADH dehydrogenase subunit4 transcripts, encoding subunits of respiratory complex IV and I, respectively, and consequently lacked cytochrome c oxidase activity. We further show that respiratory oxygen consumption by cod1 plantlets is exclusively associated with alternative oxidase activity and that alternative NADH dehydrogenases are also up-regulated in these plants. The metabolomics pattern of cod1 mutants was also deeply altered, suggesting that alternative metabolic pathways compensated for the probable resulting restriction in NADH oxidation. Being the first complex IV-deficient mutants described in higher plants, cod1 lines should be instrumental to future studies on respiration homeostasis.
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