Evidence map›Paper›PMID 25315325›Full record

Trial reportBMC medicine2014

The effects of antenatal dietary and lifestyle advice for women who are overweight or obese on neonatal health outcomes: the LIMIT randomised trial.

Jodie M Dodd, Andrew J McPhee, Deborah Turnbull, Lisa N Yelland, Andrea R Deussen, Rosalie M Grivell, Caroline A Crowther, Gary Wittert, Julie A Owens, Jeffrey S Robinson and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 6 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 6 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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  5. Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jodie M DoddThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. jodie.dodd@adelaide.edu.au.
Andrew J McPheeThe Women's and Children's Hospital, Women's and Babies Division, Department of Neonatal Medicine, Adelaide, South Australia, Australia. Andrew.McPhee@health.sa.gov.au.
Deborah TurnbullThe University of Adelaide, School of Psychology, Adelaide, South Australia, Australia. deborah.turnbull@adelaide.edu.au.
Lisa N YellandThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. lisa.yelland@adelaide.edu.au.
Andrea R DeussenThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. andrea.deussen@adelaide.edu.au.
Rosalie M GrivellThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. rosalie.grivell@adelaide.edu.au.
Caroline A CrowtherThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. caroline.crowther@adelaide.edu.au.
Gary WittertThe University of Adelaide, School of Medicine, Adelaide, South Australia, Australia. gary.wittert@adelaide.edu.au.
Julie A OwensThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. julie.owens@adelaide.edu.au.
Jeffrey S RobinsonThe University of Adelaide, School of Paediatrics and Reproductive Health, Robinson Research Institute, Adelaide, South Australia, Australia. jeffrey.robinson@adelaide.edu.au.
LIMIT Randomised Trial Group
The University of Adelaide · AUWomen's and Children's Hospital · AUUniversity of Auckland · NZWomen's & Children's Health Research Institute · AU

Funding

Limiting Weight Gain in Overweight Pregnant Women: Effects on Mother and ChildR01HL094235 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2008 to 2011
$1.3M
NHLBI NIH HHS R01 HL094235
6 · The paper itself

Abstract

backgroundOverweight and obesity during pregnancy represents a considerable health burden. While research has focused on interventions to limit gestational weight gain, there is little information describing their impact on neonatal health. Our aim was to investigate the effect on a range of pre-specified secondary neonatal outcomes of providing antenatal dietary and lifestyle advice to women who are overweight or obese.

methodsWe report a range of pre-specified secondary neonatal outcomes from a large randomised trial in which antenatal dietary and lifestyle advice was provided to women who were overweight or obese. Pregnant women were eligible for participation with a body mass index of 25 kg/m(2) or over, and singleton gestation between 10(+0) and 20(+0) weeks. Outcome measures included gestational age at birth; Apgar score below 7 at 5 minutes of age; need for resuscitation at birth; birth weight above 4.5 kg or below 2.5 kg; birth weight, length and head circumference (and Z-scores); admission to the nursery; respiratory distress syndrome; and postnatal length of stay. Data relating to the primary outcome (large for gestational age infants defined as birth weight above the 90th centile) and birth weight above 4 kg have been reported previously. Analyses used intention-to-treat principles.

resultsIn total, 2,142 infants were included in the analyses. Infants born to women following lifestyle advice were significantly less likely to have birth weight above 4.5 kg (2.15% versus 3.69%; adjusted risk ratio (aRR)=0.59; 95% confidence interval (CI) 0.36 to 0.98; P=0.04), or respiratory distress syndrome (1.22% versus 2.57%; aRR=0.47; 95% CI 0.24 to 0.90; P=0.02), particularly moderate or severe disease, and had a shorter length of postnatal hospital stay (3.94±7.26 days versus 4.41±9.87 days; adjusted ratio of means 0.89; 95% CI 0.82 to 0.97; P=0.006) compared with infants born to women who received Standard Care.

conclusionsFor women who are overweight or obese, antenatal dietary and lifestyle advice has health benefits for infants, without an increase in the risk of harm. Continued follow-up into childhood will be important to assess the longer-term effects of a reduction in high infant birth weight on risk of child obesity. Please see related articles: http://www.biomedcentral.com/1741-7015/12/161 and http://www.biomedcentral.com/1741-7015/12/201 . CLINICAL

trial registrationAustralian and New Zealand Clinical Trials Registry ( ACTRN12607000161426 ).

Indexed as

DietExerciseAdultAustraliaFemaleHumansInfant, NewbornLength of StayLife StyleMaleNew ZealandObesityPregnancyPregnancy ComplicationsPregnancy OutcomePrenatal Care

Identifiers

PMID25315325
PMCPMC4194368
OpenAlexW1979324338

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.