Trial reportPloS one2014
The potential of a high protein-low carbohydrate diet to preserve intrahepatic triglyceride content in healthy humans.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01551238 (Energy Expenditure and Sleep in Response to Protein/Carbohydrate and Fat Ratio), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Energy Expenditure and Sleep in Response to Protein/Carbohydrate and Fat Ratio
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Impact of other macronutrient composition within high-protein diet on body composition and cardiometabolic health: a systematic review, pairwise, and network meta-analysis of randomized controlled trials.International journal of obesity (2005) · 2025Pooled it
- Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2021Pooled it
- Trial
- Dietary Regulation of Hepatic Triacylglycerol Content-the Role of Eucaloric Carbohydrate Restriction with Fat or Protein Replacement.Advances in nutrition (Bethesda, Md.) · 2023Review
- Dietary Composition and Its Association with Newly Diagnosed Nonalcoholic Fatty Liver Disease and Insulin Resistance.Nutrients · 2021Article
- The low-carbohydrate-diet score is associated with resting metabolic rate: an epidemiologic study among Iranian adults.Journal of diabetes and metabolic disorders · 2021Article
- Non-alcoholic Fatty Liver Disease and Carbohydrate Restricted Diets: A Case Report and Literature Review.Cureus · 2021Article
- Review
- Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats.Nutrition & metabolism · 2020Article
- Dietary Protein and Energy Balance in Relation to Obesity and Co-morbidities.Frontiers in endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein supplementation has been shown to reduce the increases in intrahepatic triglyceride (IHTG) content induced by acute hypercaloric high-fat and high-fructose diets in humans.
objectiveTo assess the effect of a 12-wk iso-energetic high protein-low carbohydrate (HPLC) diet compared with an iso-energetic high carbohydrate-low protein (HCLP) diet on IHTG content in healthy non-obese subjects, at a constant body weight.
designSeven men and nine women [mean ± SD age: 24 ± 5 y; BMI: 22.9 ± 2.1 kg/m2] were randomly allocated to a HPLC [30/35/35% of energy (En%) from protein/carbohydrate/fat] or a HCLP (5/60/35 En%) diet by stratification on sex, age and BMI. Dietary guidelines were prescribed based on individual daily energy requirements. IHTG content was measured by 1H-magnetic resonance spectroscopy before and after the dietary intervention.
resultsIHTG content changed in different directions with the HPLC (CH2H2O: 0.23 ± 0.17 to 0.20 ± 0.10; IHTG%: 0.25 ± 0.20% to 0.22 ± 0.11%) compared with the HCLP diet (CH2H2O: 0.34 ± 0.20 vs. 0.38 ± 0.21; IHTG%: 0.38 ± 0.22% vs. 0.43 ± 0.24%), which resulted in a lower IHTG content in the HPLC compared with the HCLP diet group after 12 weeks, which almost reached statistical significance (P = 0.055).
conclusionsA HPLC vs. a HCLP diet has the potential to preserve vs. enlarge IHTG content in healthy non-obese subjects at a constant body weight.
trial registrationClinicaltrials.gov NCT01551238.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.