ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Differentiation properties of 3D scaffolds nanostructured with multi-walled carbon nanotubes on human induced pluripotent stem cells.RSC advances · 2025Article
- Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro.Advanced healthcare materials · 2025Article
- Transcriptome data are insufficient to control false discoveries in regulatory network inference.Cell systems · 2024Article
- Virtual cells in a virtual microenvironment recapitulate early development-like patterns in human pluripotent stem cell colonies.Stem cell reports · 2023Article
- Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos.GigaScience · 2022Article
- Storage temperature dictates the ability of chicken embryos to successfully resume development by regulating expression of blastulation and gastrulation genes.Frontiers in physiology · 2022Article
- Cell Surface and Functional Features of Cortical Bone Stem Cells.International journal of molecular sciences · 2021Article
- OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation.PloS one · 2021Article
- The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.Nature communications · 2019Article
- Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells.Frontiers in physiology · 2019Review
- Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling.International journal of molecular sciences · 2018Review
- coTRaCTE predicts co-occurring transcription factors within cell-type specific enhancers.PLoS computational biology · 2018Article
- Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development.Cell death & disease · 2018Article
- Diversification of spatiotemporal expression and copy number variation of the echinoid hbox12/pmar1/micro1 multigene family.PloS one · 2017Article
- Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst.Trends in genetics : TIG · 2015Review
- From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, many regulatory genes and signalling events coordinating mammalian development from blastocyst to gastrulation stages have been identified by mutational analyses and reverse-genetic approaches, typically on a gene-by-gene basis. More recent studies have applied bioinformatic approaches to generate regulatory network models of gene interactions on a genome-wide scale. Such models have provided insights into the gene networks regulating pluripotency in embryonic and epiblast stem cells, as well as cell-lineage determination in vivo. Here, we review how regulatory networks constructed for different stem cell types relate to corresponding networks in vivo and provide insights into understanding the molecular regulation of the blastocyst-gastrula transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.