GuidelineInternational urogynecology journal2015
Vaginal estrogen use in postmenopausal women with pelvic floor disorders: systematic review and practice guidelines.
Guideline in International urogynecology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Estrogen Impact on Overactive Bladder Syndrome: Female Pelvic Floor Microbiomes and Antimicrobial Peptides
Investigation of the Effect of the Female Urinary Microbiome on Incontinence
The Effects of Vaginal Estrogen and a Nonhormonal Alternative on the Vaginal and Urinary Microbiome in Women With Genitourinary Syndrome of Menopause: A Randomized Controlled Trial
Effect of Local Estriol Treatment Before Vaginal Repair Surgery on Vaginal Tissues and Early Postoperative Pelvic Floor Functions
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Uterine-preserving surgeries for the repair of pelvic organ prolapse: a systematic review with meta-analysis and clinical practice guidelines.International urogynecology journal · 2019Pooled it
- Effects of preoperative intravaginal estrogen on pelvic floor disorder symptoms in postmenopausal women with pelvic organ prolapse.American journal of obstetrics and gynecology · 2023Trial
- Trial
- Does preoperative locally applied estrogen treatment facilitate prolapse-associated symptoms in postmenopausal women with symptomatic pelvic organ prolapse? A randomised controlled double-masked, placebo-controlled, multicentre study.BJOG : an international journal of obstetrics and gynaecology · 2021Trial
- Novel minimally invasive laser treatment of urinary incontinence in women.Lasers in surgery and medicine · 2015Trial
- Histological Microstructure and In Vitro Mechanical Properties of Postmenopausal Ewe Perineal Body With and Without Estrogen Replacement Therapy.International urogynecology journal · 2026Article
- Contemporary Review of Overlap in Overactive Bladder Patients with Nephrolithiasis: Fluid Reduction in Overactive Bladder and Associated Factors Related To Nephrolithiasis.Current urology reports · 2025Review
- The Urinary, Vaginal, and Perineal Microbiome: Commonalities and Differences.International urogynecology journal · 2025Article
- [Robot-assisted minimally invasive sacrocolpopexy: a comprehensive review].Urologie (Heidelberg, Germany) · 2025Review
- Impact of Lifestyle Modifications on the Prevention and Treatment of Pelvic Organ Prolapse.International urogynecology journal · 2025Review
- At What Point in the Menstrual Cycle Are the Pelvic Floor Muscles at Their Weakest?Journal of functional morphology and kinesiology · 2024Article
- 2024 Canadian Urological Association guideline: Female stress urinary incontinence.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- New Possibilities for Hormonal Vaginal Treatment in Menopausal Women.Journal of clinical medicine · 2023Review
- Oestrogen therapy for treating pelvic organ prolapse in postmenopausal women.The Cochrane database of systematic reviews · 2023Review
- Challenges of Managing Lower Urinary Tract Symptoms in Women with Tamoxifen Use.Women's health reports (New Rochelle, N.Y.) · 2022Article
- The Relationship Between Pelvic Floor Function and Sexual Function in Perimenopausal Women.Sexual medicine · 2021Article
- Advances in molecular mechanisms of pelvic organ prolapse (Review).Experimental and therapeutic medicine · 2021Review
- Surgical Assessment of Tissue Quality during Pelvic Organ Prolapse Repair in Postmenopausal Women Pre-Treated Either with Locally Applied Estrogen or Placebo: Results of a Double-Masked, Placebo-Controlled, Multicenter Trial.Journal of clinical medicine · 2021Article
- Uterus Preservation in Case of Vaginal Prolapse Surgery Acts as a Protector against Postoperative Urinary Retention.Journal of clinical medicine · 2020Article
- Vaginal estrogen therapy is associated with increased Lactobacillus in the urine of postmenopausal women with overactive bladder symptoms.American journal of obstetrics and gynecology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisRisk of pelvic floor disorders increases after menopause and may be linked to estrogen deficiency. We aimed to systematically and critically assess the literature on vaginal estrogen in the management of pelvic floor disorders in postmenopausal women and provide evidence-based clinical practice guidelines.
methodsMEDLINE and Cochrane databases were searched from inception to July 2014 for randomized controlled trials of commercially available vaginal estrogen products compared with placebo, no treatment, or any medication for overactive bladder or urinary incontinence. We double-screened 1,805 abstracts and identified 12 eligible papers. Studies were extracted for participant information, intervention, comparator, efficacy outcomes, and adverse events, and they were individually and collectively assessed for methodological quality and strength of evidence.
resultsEvidence was generally of poor to moderate quality. Vaginal estrogen application before pelvic organ prolapse surgery improved the vaginal maturation index and increased vaginal epithelial thickness. Postoperative vaginal estrogen use after a midurethral sling resulted in decreased urinary frequency and urgency. Vaginal estrogen and immediate-release oxybutynin were similar in improvement of urinary urgency, frequency, and urgency urinary incontinence in women with overactive bladder, but oxybutynin had higher rates of side effects and discontinuation. Conversely, the addition of vaginal estrogen to immediate or extended-release tolterodine did not improve urinary symptoms more than tolterodine alone. One study reported an improvement in stress urinary incontinence with use of vaginal estrogen.
conclusionVaginal estrogen application may play a useful role as an adjunct in the management of common pelvic floor disorders in postmenopausal women.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.