ArticleFrontiers in genetics2014
Replicon: a software to accurately predict DNA replication timing in metazoan cells.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Inferring replication timing and proliferation dynamics from single-cell DNA sequencing data.Nature communications · 2024Article
- Emergence of enhancers at late DNA replicating regions.Nature communications · 2024Article
- Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers.Nature cancer · 2024Article
- Kronos scRT: a uniform framework for single-cell replication timing analysis.Nature communications · 2022Article
- Enhancing the diversity of self-replicating structures using active self-adapting mechanisms.Frontiers in genetics · 2022Article
- Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication.Molecular cell · 2021Article
- Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq.Molecular cell · 2020Article
- Model-based analysis of DNA replication profiles: predicting replication fork velocity and initiation rate by profiling free-cycling cells.Genome research · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Eukaryotic DNA replication follows a strict temporal program where genomic loci are replicated at precise times during the S phase of the cell cycle. Yet, the mechanism in control of the timing program in metazoan cells is poorly understood. In a recent publication, the authors proposed an intuitive stochastic model of DNA replication and showed that it predicts replication timing with an accuracy approaching the level of experimental biological repeats. Here, we discuss an extended software implementation of the mechanistic model: Replicon. This package allows interested researchers to predict the global replication timing program in human cells from chromatin data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.