ArticleFrontiers in physiology2014
Fractal analysis of the structural complexity of the connective tissue in human carotid bodies.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Bottom-Up Synthesis and Active Assembly of DNA Networks by Biomolecular Nanomachines.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- A Self-Similarity Logic May Shape the Organization of the Nervous System.Advances in neurobiology · 2024Article
- Fractals for an ethnography of time and addiction: Recursive and self-similar temporalities in heroin and poly-substance use.Frontiers in psychiatry · 2023Article
- Preclinical Development of Bioengineered Allografts Derived from Decellularized Human Diaphragm.Biomedicines · 2022Article
- Microscopic anatomy of the visceral fasciae.Journal of anatomy · 2017Article
- Decellularized Human Skeletal Muscle as Biologic Scaffold for Reconstructive Surgery.International journal of molecular sciences · 2015Article
- Editorial: Carotid body: a new target for rescuing neural control of cardiorespiratory balance in disease.Frontiers in physiology · 2015Article
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Authors and funding
5 authors.
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Abstract
The carotid body (CB) may undergo different structural changes during perinatal development, aging, or in response to environmental stimuli. In the previous literature, morphometric approaches to evaluate these changes have considered quantitative first order parameters, such as volumes or densities, while changes in spatial disposition and/or complexity of structural components have not yet been considered. In the present study, different strategies for addressing morphological complexity of CB, apart from the overall amount of each tissue component, were evaluated and compared. In particular, we considered the spatial distribution of connective tissue in the carotid bodies of young control subjects, young opiate-related deaths and aged subjects, through analysis of dispersion (Morisita's index), gray level co-occurrence matrix (entropy, angular second moment, variance, correlation), and fractal analysis (fractal dimension, lacunarity). Opiate-related deaths and aged subjects showed a comparable increase in connective tissue with respect to young controls. However, the Morisita's index (p < 0.05), angular second moment (p < 0.05), fractal dimension (p < 0.01), and lacunarity (p < 0.01) permitted to identify significant differences in the disposition of the connective tissue between these two series. A receiver operating characteristic (ROC) curve was also calculated to evaluate the efficiency of each parameter. The fractal dimension and lacunarity, with areas under the ROC curve of 0.9651 (excellent accuracy) and 0.8835 (good accuracy), respectively, showed the highest discriminatory power. They evidenced higher level of structural complexity in the carotid bodies of opiate-related deaths than old controls, due to more complex branching of intralobular connective tissue. Further analyses will have to consider the suitability of these approaches to address other morphological features of the CB, such as different cell populations, vascularization, and innervation.
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