Evidence map›Paper›PMID 25422002›Full record

ReviewNature reviews. Rheumatology2015

Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation.

Fabiana B Benatti, Bente K Pedersen

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07222696 (Pilot Randomized Trial of Health Coaching for People With Rheumatoid Arthritis to Improve Mental Well-Being), which is not on this map. Cited by 196 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 7 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07222696 narecruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Randomized Trial of Health Coaching for People With Rheumatoid Arthritis to Improve Mental Well-Being

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2026 to 2030Enrolled250ConditionsRheumatoid Arthritis (RAArmsPeer Coach, Healthy Horizons
3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 7 syntheses or guidelines pooled it, 463 citations in OpenAlex.

  1. Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Fabiana B BenattiRheumatology Division, School of Medicine, University of Sao Paolo, Avenida Dr. Enéas de Carvalho Aguiar, 255, 05903-900, Sao Paolo, Brazil.
Bente K PedersenRigshospitalet 7641, Centre of Inflammation and Metabolism and The Centre for Physical Activity Research, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Rigshospitalet · DKUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent systemic inflammation, a typical feature of inflammatory rheumatic diseases, is associated with a high cardiovascular risk and predisposes to metabolic disorders and muscle wasting. These disorders can lead to disability and decreased physical activity, exacerbating inflammation and the development of a network of chronic diseases, thus establishing a 'vicious cycle' of chronic inflammation. During the past two decades, advances in research have shed light on the role of exercise as a therapy for rheumatic diseases. One of the most important of these advances is the discovery that skeletal muscle communicates with other organs by secreting proteins called myokines. Some myokines are thought to induce anti-inflammatory responses with each bout of exercise and mediate long-term exercise-induced improvements in cardiovascular risk factors, having an indirect anti-inflammatory effect. Therefore, contrary to fears that physical activity might aggravate inflammatory pathways, exercise is now believed to be a potential treatment for patients with rheumatic diseases. In this Review, we discuss how exercise disrupts the vicious cycle of chronic inflammation directly, after each bout of exercise, and indirectly, by improving comorbidities and cardiovascular risk factors. We also discuss the mechanisms by which some myokines have anti-inflammatory functions in inflammatory rheumatic diseases.

Indexed as

Exercise TherapyAdiposityBody CompositionHumansInflammationInterleukin-6Muscle, SkeletalRheumatic DiseasesScleroderma, SystemicTumor Necrosis Factor-alphaInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID25422002
OpenAlexW2158302351

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.