Evidence mapPaperPMID 25446696Full record

ArticleAmerican journal of obstetrics and gynecology2015

Associations of trimester-specific gestational weight gain with maternal adiposity and systolic blood pressure at 3 and 7 years postpartum.

Jessica R Walter, Wei Perng, Ken P Kleinman, Sheryl L Rifas-Shiman, Janet W Rich-Edwards, Emily Oken

Open access · bronzeAbstract read
In one paragraph

Article in American journal of obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 136 citations in OpenAlex.

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  20. Factors associated with early gestational weight gain among women with pre-pregnancy overweight or obesity.Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jessica R WalterHarvard Medical School, Boston, MA.
Wei PerngObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Ken P KleinmanObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Sheryl L Rifas-ShimanObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Janet W Rich-EdwardsChanning Laboratory and Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Boston, MA.
Emily OkenObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA. Electronic address: emily_oken@hphc.org.
Harvard University · USBrigham and Women's Hospital · US

Funding

NUTRITION IN PREGNANCY, BIRTH WEIGHT, &CHILDHOOD ASTHMAR01HL064925 · HARVARD PILGRIM HEALTH CARE, INC. · 2000 to 2004
$4.4M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · HARVARD PILGRIM HEALTH CARE, INC. · 1998 to 2025
$3.6M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · KAISER FOUNDATION RESEARCH INSTITUTE · 2025 to 2025
$700k
NHLBI NIH HHS R01 HL064925NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD034568NICHD NIH HHS R01 HD34568NICHD NIH HHS R37 HD034568NIDDK NIH HHS P30 DK092924NIDDK NIH HHS R21 DK073739
6 · The paper itself

Abstract

objectiveOur objective was to examine the associations of total and trimester-specific gestational weight gain (GWG) rate with postpartum maternal weight and cardiometabolic risk. We hypothesized that first-trimester GWG would be most strongly associated with long-term maternal health. STUDY

designWe studied 801 women enrolled during the first trimester of pregnancy in the Boston-area Project Viva cohort 1999 through 2002. At 3 years postpartum we measured maternal weight, waist circumference (WC), and systolic blood pressure (SBP) and collected fasting blood from a subset. At 7 years postpartum we again measured weight and WC. We used multivariable linear regression to evaluate relations of total and trimester-specific GWG rate with weight change (vs self-reported prepregnancy weight) and WC at each time point, stratified by prepregnancy weight, as well as associations with SBP and insulin resistance at 3 years.

resultsMedian age at enrollment was 34.0 years (range, 16.4-44.9); 65% were white. Mean (SD) total GWG rate was 0.38 (0.14) kg/wk. Women gained weight faster during the second (0.47 [0.19] kg/wk) and third (0.44 [0.22] kg/wk) trimesters than the first (0.22 [0.22] kg/wk). Total and first-trimester GWG rate were most strongly associated with postpartum weight change. Among normal-weight women, each 1-SD increase in total and first-trimester GWG rate corresponded with 0.85 (95% confidence interval [CI], 0.07-1.63) kg and 2.08 (1.32-2.84) kg greater weight change at 3 and 7 years postpartum, respectively, but there was not strong evidence of association for either second- (-0.30 kg; 95% CI, -1.08 to 0.48) or third- (-0.26 kg; 95% CI, -1.08 to 0.55) trimester GWG. First-trimester GWG rate also related to 3-year postpartum weight change in overweight (2.28 kg; 95% CI, 0.95-3.61) and obese (2.47 kg; 95% CI, 0.98-3.97) women. Greater total and first-trimester GWG rate were associated with larger WC and higher SBP but not insulin resistance.

conclusionIn this observational cohort, first-trimester weight gain was more strongly associated with maternal weight retention as well as higher WC and blood pressure than second- or third-trimester gain. Interventions targeting GWG beginning very early in pregnancy may benefit long-term maternal health.

Indexed as

AdiposityBlood PressureAdolescentAdultBody WeightFemaleFollow-Up StudiesHumansHypertensionInsulin ResistanceModels, StatisticalObesityOverweightPregnancyPregnancy TrimestersProspective Studiescardiometabolic healthgestational weight gainpostpartum periodpregnancy

Identifiers

PMID25446696
PMCPMC4387018
OpenAlexW1976594742

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.