Trial reportBehavioural brain research2015
The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste.
Trial report in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex/gender differences in neural correlates of food stimuli: a systematic review of functional neuroimaging studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- The role of the caudate nucleus in taste function: a comprehensive narrative review.Frontiers in neuroscience · 2026Review
- Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission.Nutrients · 2020Review
- High body mass index, brain metabolism and connectivity: an unfavorable effect in elderly females.Aging · 2019Article
- Greater Reward-Related Neuronal Response to Hedonic Foods in Women Compared with Men.Obesity (Silver Spring, Md.) · 2018Article
- Taste assessment in normal weight and overweight individuals with co-occurring Binge Eating Disorder.Appetite · 2017Article
- Reorganization of brain connectivity in obesity.Human brain mapping · 2017Article
- Brain imaging demonstrates a reduced neural impact of eating in obesity.Obesity (Silver Spring, Md.) · 2016Article
- Emotional susceptibility trait modulates insula responses and functional connectivity in flavor processing.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We have previously shown that propensity for weight gain, energy balance state and sex are important determinants of the neuronal response to visual food cues. It is not clear, though, whether these factors also impact the neuronal response to taste. The objective of this study was to examine the neuronal response to sweet taste during energy imbalance in men and women recruited to be obesity-prone (OP) or obesity-resistant (OR). OP (13 men and 12 women) and OR (12 men and 12 women) subjects were studied after 1 day of eucaloric, overfed and underfed conditions in a randomized crossover design. On each test day, fMRI was performed in the respective acute fed state while subjects received in random order 60 trials each of 1M sucrose solution (SU), or artificial saliva (AS) following a visual cue predicting the taste. The neuronal response to SU versus AS expectation was significantly greater in the amygdala, orbitofrontal cortex, putamen and insula in OR versus OP; SU receipt was not different between groups. There were also sex-based differences with men having greater neuronal response to SU versus AS receipt in the caudate than women. The results, however, were not impacted by the state of energy balance. In summary, response to expectation but not receipt of basic sweet taste was different in OR compared to OP, highlighting the importance of learning and conditioning in the propensity to gain weight. Response to sucrose taste receipt was stronger in men than women, raising questions about the effect of sex hormones on brain response to food.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.