ArticlePsychiatry research2014
The neural correlates of emotional face-processing in adolescent depression: a dimensional approach focusing on anhedonia and illness severity.
Article in Psychiatry research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Meta-Analysis of the RDoC Social Processing Domain across Units of Analysis in Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Pooled it
- Neural response to reward uncertainty in adolescents with mood and anxiety symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered Habenula Resting-State Functional Connectivity and Spatial Associations with Neurotransmitter Receptor Distribution of Major Depressive Disorder with and without Anhedonia.Neuropsychiatric disease and treatment · 2026Article
- Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Prefrontal-Dependent and Gender-Specific Modulation of Guilt Emotion on Human Early Visual Perception.Behavioral sciences (Basel, Switzerland) · 2025Article
- Frontocortical activity and emotional experience in the context of daily life events.Social cognitive and affective neuroscience · 2025Article
- Social Dysfunction and Neural Processing of Emotional Valence Across Depressive and Anxiety Disorders.Depression and anxiety · 2024Article
- Self-compassion and dorsolateral prefrontal cortex activity during sad self-face recognition in depressed adolescents.Psychological medicine · 2022Article
- Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.Frontiers in psychiatry · 2021Review
- Turning down the heat: Neural mechanisms of cognitive control for inhibiting task-irrelevant emotional information during adolescence.Neuropsychologia · 2019Article
- Psychophysiological correlates between emotional response inhibition and posttraumatic stress symptom clusters.Scientific reports · 2018Article
- Dorsomedial Prefrontal Activity to Sadness Predicts Later Emotion Suppression and Depression Severity in Adolescent Girls.Child development · 2018Article
- The neurobiology of self-face recognition in depressed adolescents with low or high suicidality.Journal of abnormal psychology · 2016Article
- Divergent relationship of depression severity to social reward responses among patients with bipolar versus unipolar depression.Psychiatry research. Neuroimaging · 2016Article
- Neural correlates of self-perceptions in adolescents with major depressive disorder.Developmental cognitive neuroscience · 2016Article
- Altered neural function to happy faces in adolescents with and at risk for depression.Journal of affective disorders · 2016Article
- Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect.Developmental cognitive neuroscience · 2016Article
- Task and Resting-State fMRI Reveal Altered Salience Responses to Positive Stimuli in Patients with Major Depressive Disorder.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Deficits in emotion processing, a known clinical feature of major depressive disorder (MDD), have been widely investigated using emotional face paradigms and neuroimaging. However, most studies have not accounted for the high inter-subject variability of symptom severity. Similarly, only sparse research has focused on MDD in adolescence, early in the course of the illness. Here we sought to investigate neural responses to emotional faces using both categorical and dimensional analyses with a focus on anhedonia, a core symptom of MDD associated with poor outcomes. Nineteen medication-free depressed adolescents and 18 healthy controls (HC) were scanned during presentation of happy, sad, fearful, and neutral faces. ANCOVAs and regressions assessed group differences and relationships with illness and anhedonia severity, respectively. Findings included a group by valence interaction with depressed adolescents exhibiting decreased activity in the superior temporal gyrus (STG), putamen and premotor cortex. Post-hoc analyses confirmed decreased STG activity in MDD adolescents. Dimensional analyses revealed associations between illness severity and altered responses to negative faces in prefrontal, cingulate, striatal, and limbic regions. However, anhedonia severity was uniquely correlated with responses to happy faces in the prefrontal, cingulate, and insular regions. Our work highlights the need for studying specific symptoms dimensionally in psychiatric research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.