Evidence map›Paper›PMID 25451450›Full record

ArticleJournal of affective disorders2015

Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.

Kaya K Jacobsen, Caroline M Nievergelt, Tetyana Zayats, Tiffany A Greenwood, Verneri Anttila, Hagop S Akiskal, BiGS Consortium, IHG Consortium, Jan Haavik, Ole Bernt Fasmer and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Frontiers in neuroscience · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 20 institutions in 9 countries.

Kaya K JacobsenKG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: kja098@biomed.uib.no.
Caroline M NievergeltDepartment of Psychiatry, University of California, San Diego, USA.
Tetyana ZayatsKG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Tiffany A GreenwoodDepartment of Psychiatry, University of California, San Diego, USA.
Verneri AnttilaAnalytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Hagop S AkiskalDepartment of Psychiatry, University of California, San Diego, USA; Department of Psychiatry, VA Hospital, San Diego, USA.
BiGS Consortium
IHG Consortium
Jan HaavikKG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Ole Bernt FasmerKG Jebsen Center for Neurophyciatric research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
John R KelsoeDepartment of Psychiatry, University of California, San Diego, USA; Department of Psychiatry, VA Hospital, San Diego, USA.
Stefan JohanssonKG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway.
Ketil J OedegaardKG Jebsen Center for Neurophyciatric research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Leiden University Medical Center · NLUniversity of California, San Diego · USInstitute for Molecular Medicine Finland · FIUniversity of Bergen · NOUniversity of Oulu · FIdeCODE Genetics (Iceland) · ISEssen University Hospital · DETampere University · FIHaukeland University Hospital · NOIndiana University – Purdue University Indianapolis · USLudwig-Maximilians-Universität München · DEUniversity of Helsinki · FIUniversity of Michigan–Ann Arbor · USHarvard University · USHoward University · USMax Planck Institute of Psychiatry · DEPortland VA Medical Center · USScripps Research Institute · USUniversität Ulm · DEUniversity of Bristol · GB

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, R JEFFREY · 1985 to 2010
$74.3M
Pharmacogenomics of Mood Stabilizer Response in Bipolar DisorderU01MH092758 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2010 to 2014
$6.2M
Genomic Association Study of Bipolar DisorderR01MH078151 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2007 to 2009
$5.5M
Genomic studies of bipolar disorder and chromosome 22R01MH068503 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2004 to 2008
$3.1M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1M
Mapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0M
Collaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9M
Intramural NIH HHS Z01 MH002810NCRR NIH HHS M01 RR000827NIMH NIH HHS 1Z01MH002810-01NIMH NIH HHS K01 MH087889NIMH NIH HHS MH059567NIMH NIH HHS MH078151NIMH NIH HHS MH081804NIMH NIH HHS MH68503NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068NIMH NIH HHS R01 MH068503NIMH NIH HHS R01 MH078151NIMH NIH HHS R01 MH081804NIMH NIH HHS R01 MH093500NIMH NIH HHS R01MH59533NIMH NIH HHS R01 MH59535NIMH NIH HHS R01MH59545NIMH NIH HHS R01 MH59553NIMH NIH HHS R01 MH59567NIMH NIH HHS R01 MH60068NIMH NIH HHS U01 MH092758NIMH NIH HHS U01 MH46274NIMH NIH HHS U01 MH46280NIMH NIH HHS U01 MH46282
6 · The paper itself

Abstract

backgroundMigraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine.

methodsWe performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS).

resultsWe identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97 × 10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases. LIMITATIONS: Our study is based on self-reported migraine.

conclusionsNBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder.

Indexed as

Polymorphism, Single NucleotideAdultBipolar DisorderCarrier ProteinsComorbidityFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMigraine DisordersNerve Tissue ProteinsCarrier ProteinsNBEA protein, humanNerve Tissue ProteinsBipolar disorderGeneticsMigraineNBEANeurobeachin

Identifiers

PMID25451450
PMCPMC4394021
OpenAlexW1687266585

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.