ReviewJournal of diabetes and its complications2015
Complications and comorbidities of T2DM in adolescents: findings from the TODAY clinical trial.
Review in Journal of diabetes and its complications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00081328. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Endothelial Peripheral Arterial Tonometry (Endo-PAT 2000) use in paediatric patients: a systematic review.BMJ open · 2023Pooled it
- The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis.Cardiovascular diabetology · 2017Pooled it
- A Systematic Review of Transitional Care for Emerging Adults with Diabetes.Journal of pediatric nursingPooled it
- Circulating adhesion molecules and associations with HbA1c, hypertension, nephropathy, and retinopathy in the Treatment Options for type 2 Diabetes in Adolescent and Youth study.Pediatric diabetes · 2020 · on this mapTrial
- A tailored intervention to promote uptake of retinal screening among young adults with type 2 diabetes - an intervention mapping approach.BMC health services research · 2018Trial
- Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.JAMA pediatrics · 2018 · on this mapTrial
- A Virtual Living Lab Platform Codeveloped for Mental Health in Youth-Onset Type 2 Diabetes (BrightSpark Care Lab): Protocol for a Mixed Methods Study.JMIR research protocols · 2026Article
- Electroacupuncture in glycemic control: Transitioning from clinical controversies to potential basic research.World journal of diabetes · 2025Review
- High predicted cardiac event risk in youth with obesity and type 2 diabetes: a pooled cohort analysis.Cardiovascular diabetology · 2025Article
- Exercise Interventions for Metabolic Diseases: An Analysis of the Evolution of Aerobic Exercise Bibliometrics in the Field of Type 2 Diabetes Mellitus.Healthcare (Basel, Switzerland) · 2025Review
- International expert consensus on surgery for type 2 diabetes mellitus.BMC endocrine disorders · 2025Review
- Multiple long-term conditions as the next transition in the global diabetes epidemic.Communications medicine · 2025Review
- Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations.Aging cell · 2024Article
- Inaccurate diagnosis of diabetes type in youth: prevalence, characteristics, and implications.Scientific reports · 2024Article
- Characteristics of adolescents referred for bariatric surgery in Abu Dhabi, United Arab Emirates.Frontiers in pediatrics · 2024Article
- Paediatric obesity: Documentation, screening, and pharmacotherapy in a national cohort.Pediatric obesity · 2023Article
- Imprecise Diagnosis of Diabetes Type in Youth: Prevalence, Characteristics, and Implications.Research square · 2023Article
- Clinical Characterization of Data-Driven Diabetes Clusters of Pediatric Type 2 Diabetes.Pediatric diabetes · 2023Article
- Integration of Time-Based Recommendations with Current Pediatric Health Behavior Guidelines: Implications for Obesity Prevention and Treatment in Youth.Current obesity reports · 2022Review
- Obesity Pillars roundtable: Metabolic and bariatric surgery in children and adolescents.Obesity pillars · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
With the rise in childhood obesity, type 2 diabetes mellitus (T2DM) has been recognized to occur in adolescents with increasing frequency. Although much is known about T2DM in adults, few studies have examined the treatment and complications of T2DM in youth. The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study was designed to evaluate the efficacy of various treatments and provided a unique opportunity to study the disease progression and appearance of complications in a pediatric cohort with recent onset of the disease. In the TODAY study, hypertension was present in 11.6% of the population at baseline and increased to 33.8% by the end of the study. Prevalence of high-risk LDL-cholesterol rose from 4.5% at baseline to 10.7% at the end of the study. Microalbuminuria was found in 6.3% of the cohort at baseline and increased to 16.6%. Retinopathy was not assessed upon entry into TODAY, but was present in 13.9% of the TODAY cohort at the end of the study. Experience to date indicates that these complications and comorbidities are similar to those seen in adults, but occur on an accelerated timeline. The early manifestation of diabetes complications in youth-onset T2DM suggests that this group will be burdened with the tangible consequences of cardiovascular disease, nephropathy, and retinopathy in the third and fourth decades of life. It is hoped that through an early, aggressive approach to treatment and prevention, we may be able to curb the onset and progression of these potentially devastating outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.