ReviewTrends in genetics : TIG2015
Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.
Review in Trends in genetics : TIG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The Endo-GeneScreen platform identifies drug-like probes that regulate endogenous protein levels within physiological contexts.Nature communications · 2025Article
- VIBRANT: spectral profiling for single-cell drug responses.Nature methods · 2024Article
- Early Pharmacological Profiling of Antiproliferative Compounds by Live Cell Imaging.Molecules (Basel, Switzerland) · 2022Article
- Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery.International journal of molecular sciences · 2020Review
- High content analysis in amyotrophic lateral sclerosis.Molecular and cellular neurosciences · 2017Review
- Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening.Molecular and cellular neurosciences · 2017Review
- Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.Nature protocols · 2016Article
- Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Over the past decade, tremendous progress in high-throughput small molecule-screening methods has facilitated the rapid expansion of phenotype-based data. Parallel advances in genomic characterization methods have complemented these efforts by providing a growing list of annotated cell line features. Together, these developments have paved the way for feature-based identification of novel, exploitable cellular dependencies, subsequently expanding our therapeutic toolkit in cancer and other diseases. Here, we provide an overview of the evolution of phenotypic small-molecule profiling and discuss the most significant and recent profiling and analytical efforts, their impact on the field, and their clinical ramifications. We additionally provide a perspective for future developments in phenotypic profiling efforts guided by genomic science.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.