ReviewCellular and molecular life sciences : CMLS2015
Physical and mechanical regulation of macrophage phenotype and function.
Review in Cellular and molecular life sciences : CMLS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
206 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanical stress-mediated immune and inflammatory regulation:Frontiers in medicine · 2025Pooled it
- TTNCell reports · 2026Article
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- Rational design of immunological programs for functional regenerative niches.Materials today. Bio · 2026Review
- Hyposaline LUSO Mineral Water Drives Murine Macrophage Polarization Towards an Anti-Inflammatory M2 Phenotype.Food science & nutrition · 2026Article
- In vivo CAR-M therapy: advancing precision delivery and programmable immune remodeling.Cell communication and signaling : CCS · 2026Review
- Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis.Nature biomedical engineering · 2026Article
- Penicillin-streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation.Mechanobiology in medicine · 2026Article
- The Collapse of the Collagen Sponge Microstructure Triggers an Inflammatory Response of Macrophages via theBioengineering (Basel, Switzerland) · 2026Article
- Recent progress in macrophage-mediated tendon injury and healing.Histology and histopathology · 2026Review
- Mechanobiological Specialization of Choroid Plexus Macrophages Defined by Titin Expression.bioRxiv : the preprint server for biology · 2026Article
- Multilayer dual-porosity 3D printed scaffolds to recreate the anisotropic microenvironment of the hyaline cartilage.Materials today. Bio · 2025Article
- Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment.Bone research · 2025Review
- Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics.Materials today. Bio · 2025Review
- Topographical Patterning of Cell-Repellent Interfaces for Immune-Stealth Implantable Electronics via Multiphoton Ablation Lithography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Autologous and synthetic vascular grafts trigger different host responses in the anastomotic regions and in the perivascular adipose tissue during the early healing phase.Materials today. Bio · 2025Article
- Macrophage Polarization Profiling in Dynamic Culture System.Cellular and molecular bioengineering · 2025Article
- Fenchone attenuates CD68-dependent 7-ketocholesterol accumulation, cholesterol dyshomeostasis and inflammatory responses via modulation of macrophage polarization.Inflammopharmacology · 2025Article
- Advances in the study of mechanisms underlying olfactory dysfunction in obstructive sleep apnea:a narrative review.Sleep and biological rhythms · 2025Review
- Targeting the redox neuroinflammatory nexus: insights into Alzheimer's and Parkinson's diseases.Inflammopharmacology · 2025Review
146 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Macrophages are tissue-resident immune cells that play a critical role in maintaining homeostasis and fighting infection. In addition, these cells are involved in the progression of many pathologies including cancer and atherosclerosis. In response to a variety of microenvironmental stimuli, macrophages can be polarized to achieve a spectrum of functional phenotypes. This review will discuss some emerging evidence in support of macrophage phenotypic regulation by physical and mechanical cues. As alterations in the physical microenvironment often underlie pathophysiological states, an understanding of their effects on macrophage phenotype and function may help provide mechanistic insights into disease pathogenesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.