ER morphology: sculpting with XendoU.

Guohua Zhao, Craig Blackstone

Open access · bronzeAbstract readComment

In one paragraph

Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact, top 93% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

Simultaneous induction of immunogenic cell death and PD-L1 downregulation by bufalin-based nanovaccines for potentiate HCC immunotherapy.Materials today. Bio · 2025
Article
Molecular basis for the calcium-dependent activation of the ribonuclease EndoU.Nature communications · 2025
Article
Biomolecular NMR assignments · 2024
Article
Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy.Cells · 2022
Review
Chromatolysis: Do injured axons regenerate poorly when ribonucleases attack rough endoplasmic reticulum, ribosomes and RNA?Developmental neurobiology · 2018
Review

4 · The record

Corrections and comments

Comment on
The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation.2014

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Guohua ZhaoCell Biology Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2C-913, 9000 Rockville Pike, Bethesda, MD 20892-3738, USA.

Craig BlackstoneCell Biology Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2C-913, 9000 Rockville Pike, Bethesda, MD 20892-3738, USA. Electronic address: blackstc@ninds.nih.gov.

National Institutes of Health · US

Funding

Molecular Pathogenesis Of Hereditary Spastic ParaplegiasZIANS002992 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI BLACKSTONE, CRAIG · 2009 to 2021

$20.6M

Intramural NIH HHS Z99 NS999999

6 · The paper itself

Abstract

Endoplasmic reticulum (ER) sheet membranes are covered with ribosomes and RNAs that are involved in protein synthesis. A new study reveals that a calcium-activated endoribonuclease of the EndoU protein family promotes the formation of tubular ER networks, contributing to dynamic shaping of the ER in cells.

Indexed as

RNA StabilityAnimalsEndoplasmic ReticulumEndoribonucleasesHumansNuclear EnvelopeRNA, MessengerXenopus laevisXenopus ProteinsEndoribonucleasesRNA, MessengerXenopus Proteins

Identifiers

PMID25514011

DOI10.1016/j.cub.2014.11.005

PMCPMC5585780

OpenAlexW1976119316

What Socratic holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.