ReviewProgress in cardiovascular diseases
Exercise interventions and peripheral arterial function: implications for cardio-metabolic disease.
Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03355469. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
Who cites it
38 citing papers in PubMed, 78 citations in OpenAlex.
- Cardiometabolic Effects of High-Intensity Hybrid Functional Electrical Stimulation Exercise after Spinal Cord Injury.PM & R : the journal of injury, function, and rehabilitation · 2021Trial
- Combined Exercise Training Performed by Elderly Women Reduces Redox Indexes and Proinflammatory Cytokines Related to Atherogenesis.Oxidative medicine and cellular longevity · 2019Trial
- Effects of 12-week aquatic HIIT on blood pressure lipid profile and BaPWV in postmenopausal women with different ACE genotypes.Scientific reports · 2026Article
- Potential role of FNDC5 in exercise-induced improvement of cognitive function.Journal of Zhejiang University. Science. B · 2025Review
- Review
- Improvements in Exercise for Alzheimer's Disease: Highlighting FGF21-Induced Cerebrovascular Protection.Neurochemical research · 2025Review
- Development and validation of nomograms for predicting cardiovascular disease risk in patients with prediabetes and diabetes.Scientific reports · 2024Article
- A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise.Molecular neurobiology · 2024Article
- Review
- Investigation of the involvement of platelet-activating factor in the control of hypertension by aerobic training. A randomized controlled trial.Biology of sport · 2024Article
- Thromboxane-induced cerebral microvascular rarefaction predicts depressive symptom emergence in metabolic disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Effects of aquatic and land high intensity interval training on hemodynamics and vascular function of middle-aged men.Frontiers in physiology · 2024Article
- Synergistic effects of exercise and catalase overexpression on gut microbiome.Environmental microbiology · 2022Article
- L-Arginine Enhances the Effects of Cardiac Rehabilitation on Physical Performance: New Insights for Managing Cardiovascular Patients During the COVID-19 Pandemic.The Journal of pharmacology and experimental therapeutics · 2022Article
- Exercise capacity, cardiac and endothelial function in adults with repaired tetralogy of Fallot.International journal of cardiology. Congenital heart disease · 2022Article
- Effects of exercise modalities on decreased blood pressure in patients with hypertension.Frontiers in physiology · 2022Article
- A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation.Frontiers in physiology · 2022Review
- Cardiovascular risk moderates the effect of aerobic exercise on executive functions in older adults with subcortical ischemic vascular cognitive impairment.Scientific reports · 2021Article
- Exercise and Circulating Microparticles in Healthy Subjects.Journal of cardiovascular translational research · 2021Review
- Responders and non-responders to aerobic exercise training: beyond the evaluation ofPhysiological reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Physical inactivity is a major risk factor for the development of obesity and other cardiovascular (CV) disease (CVD). Vascular endothelial dysfunction is a key event in the development of CVD and is associated with a sedentary lifestyle in otherwise healthy adults. In addition, vascular endothelial dysfunction may be exacerbated in sedentary individuals who are obese and insulin resistant, since excess body fat is associated with elevated levels of pro-atherogenic inflammatory adipokines and cytokines that reduce the nitric oxide (NO) and other upstream paracrine signaling substances which reduces vascular health. Since blood flow-related shear stress is a major stimulus to NO release from the endothelium, disturbed flow or low shear stress is the likely mechanism by which vascular endothelial function is altered with inactivity. Evidence shows that regular physical exercise has beneficial effects on CVD and the risk factors that promote peripheral arterial function and health. Both aerobic and resistance exercise training are generally believed to improve endothelial function and are commonly recommended for CV health, including the management of obesity, hypertension, and insulin resistance. However, many factors including age, disease status, and race appear to influence these outcomes. Although evidence supporting the health benefits of exercise is compelling, the optimum prescription (volume and intensity) and the exact mechanism underlying the effects of exercise training on arterial function and cardiometabolic risk has yet to be identified. The focus of this review will be on the evidence supporting exercise interventions for peripheral arterial function.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.