ArticleJournal of materials chemistry. B2014
Silk Nanofiber Hydrogels with Tunable Modulus to Regulate Nerve Stem Cell Fate.
Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Development of millifluidic device and electronic extrusion system for fabrication of sodium alginate/carbon nanotube microfibers.Scientific reports · 2025Article
- [Research progress on silk fibroin-nerve guidance conduits for peripheral nerve injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- In Vitro and In Vivo Biodegradation of Silk Fabric Scaffolds.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025Article
- Emerging biomimetic biopolymer-based composites: advancing accessible and sustainable neural disease models and therapeutics.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Stimulus-Responsive, Gelatin-Containing Supramolecular Nanofibers as Switchable 3D Microenvironments for Cells.Polymers · 2022Article
- Silk Fibroin Hydrogels Could Be Therapeutic Biomaterials for Neurological Diseases.Oxidative medicine and cellular longevity · 2022Review
- Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System.Pharmaceutics · 2021Review
- The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors.Frontiers in bioengineering and biotechnology · 2021Review
- Robust Nanofiber Mats Exfoliated From Tussah Silk for Potential Biomedical Applications.Frontiers in bioengineering and biotechnology · 2021Article
- Silk fibroin nanoscaffolds for neural tissue engineering.Journal of materials science. Materials in medicine · 2020Article
- Silk fibroin hydrogels from the Colombian silkworm Bombyx mori L: Evaluation of physicochemical properties.PloS one · 2019Article
- Laminin-Coated Electrospun Regenerated Silk Fibroin Mats Promote Neural Progenitor Cell Proliferation, Differentiation, and SurvivalFrontiers in bioengineering and biotechnology · 2019Article
- Current and novel polymeric biomaterials for neural tissue engineering.Journal of biomedical science · 2018Review
- Biopolymer nanofibrils: structure, modeling, preparation, and applications.Progress in polymer science · 2018Article
- In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application.Scientific reports · 2018Article
- Bioactive Silk Hydrogels with Tunable Mechanical Properties.Journal of materials chemistry. B · 2018Article
- The effect of four types of artificial nerve graft structures on the repair of 10-mm rat sciatic nerve gap.Journal of biomedical materials research. Part A · 2017Article
- Bioactive Natural Protein-Hydroxyapatite Nanocarriers for Optimizing Osteogenic Differentiation of Mesenchymal Stem Cells.Journal of materials chemistry. B · 2016Article
- Silk scaffolds with tunable mechanical capability for cell differentiation.Acta biomaterialia · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Reconstruction of damaged nerves remains a significant unmet challenge in clinical medicine. To foster improvements, the control of neural stem cell (NSC) behaviors, including migration, proliferation and differentiation are critical factors to consider. Topographical and mechanical stimulation based on the control of biomaterial features is a promising approach, which are usually studied separately. The synergy between topography and mechanical rigidity could offer new insights into the control of neural cell fate if they could be utilized concurrently in studies. To achieve this need, silk fibroin self-assembled nanofibers with a beta-sheet-enriched structure are formed into hydrogels. Stiffness is tuned using different annealing processes to enable mechanical control without impacting the nanofiber topography. Compared with nonannealed nanofibers, NSCs on methanol annealed nanofibers with stiffness similar to nerve tissues differentiate into neurons with the restraint of glial differentiation, without the influence of specific differentiation biochemical factors. These results demonstrate that combining topographic and mechanical cues provides the control of nerve cell behaviors, with potential for neurogenerative repair strategies.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.