Evidence map›Paper›PMID 25533965›Full record

ArticleCirculation2015

Harnessing the nitrate-nitrite-nitric oxide pathway for therapy of heart failure with preserved ejection fraction.

Rebecca Vanderpool, Mark T Gladwin

Registry-linked trialAbstract readEditorialComment
PubMed Publisher
In one paragraph

Article in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01431313 (A Dose Escalation Study to Evaluate the Effect of Inhaled Nitrite on Cardiopulmonary Hemodynamics in Subjects With Pulmonary Hypertension), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01431313 phase2completednot on this map

A Dose Escalation Study to Evaluate the Effect of Inhaled Nitrite on Cardiopulmonary Hemodynamics in Subjects With Pulmonary Hypertension

TypeinterventionalSponsorSchmidhofer, Mark, MDRan2012 to 2017Enrolled48ConditionsPulmonary Hypertension, Heart Failure, DiastolicArmsInhaled Nitrite
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. The role and mechanism of AMPK in pulmonary hypertension.Therapeutic advances in respiratory disease
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rebecca VanderpoolFrom the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.V., M.T.G.); and Division of Pulmonary, Allergy and Critical Care Medicine, UPMC and University of Pittsburgh, Pittsburgh, PA (R.V., M.T.G.).
Mark T GladwinFrom the Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA (R.V., M.T.G.); and Division of Pulmonary, Allergy and Critical Care Medicine, UPMC and University of Pittsburgh, Pittsburgh, PA (R.V., M.T.G.). gladwinmt@upmc.edu.

Funding

Training in Translational Research in Pulmonary Vascular BiologyT32HL110849 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$257k
NHLBI NIH HHS T32 HL110849
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBlood PressureExercise TestExercise ToleranceFemaleHeart FailureHumansMaleMuscle, SkeletalNitratesRadial ArterySodium NitriteStroke VolumeVasodilationNitratesSodium NitriteEditorialsnitratesnitric oxide

Identifiers

PMID25533965

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.