ArticleMolecular reproduction and development2015
Role of focal adhesion kinase in oocyte-follicle communication.
Article in Molecular reproduction and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genetic Architecture of Egg Production Traits in Chickens: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Overview of Gene Expression Dynamics during Human Oogenesis/Folliculogenesis.International journal of molecular sciences · 2023Pooled it
- IL17 signaling promotes oocyte developmental competence acquisition during maturation.Cellular & molecular biology letters · 2026Article
- Long-term tamoxifen impacts the ovary but not preimplantation embryo development†.Biology of reproduction · 2026Article
- Iron-responsive ZNF185 overexpression drives mitochondrial fission and endoplasmic reticulum stress via cytoskeletal remodeling in granulosa cells.Cell death discovery · 2025Article
- Small and Large Extracellular Vesicles From Human Preovulatory Follicular Fluid Display Distinct ncRNA Cargo Profiles and Differential Effects on KGN Granulosa Cells.Journal of extracellular vesicles · 2025Article
- Investigation of Fructus Ligustri Lucidi for Premature Ovarian Insufficiency based on a Network Pharmacology and Experiment Verifications.Combinatorial chemistry & high throughput screening · 2025Article
- DBP Exposure Affects Oocyte Fertilization Via Extracellular Vesicles-Derived miR-116-5p in Ovarian Granulosa Cells Through Downregulating FOXO3a Expression.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Seasonal environmental fluctuations alter the transcriptome dynamics of oocytes and granulosa cells in beef cows.Journal of ovarian research · 2024Article
- Article
- Paxillin knockout in mouse granulosa cells increases fecundity†.Biology of reproduction · 2023Article
- Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes.Life science alliance · 2023Article
- Variations of follicular fluid extracellular vesicles miRNAs content in relation to development stage and season in buffalo.Scientific reports · 2022Article
- MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis†.Biology of reproduction · 2022Article
- Mammalian cumulus-oocyte complex communication: a dialog through long and short distance messaging.Journal of assisted reproduction and genetics · 2022Review
- Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation.Frontiers in endocrinology · 2022Article
- Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication.Theranostics · 2022Article
- Follicular extracellular vesicles enhance meiotic resumption of domestic cat vitrified oocytes.Scientific reports · 2020Article
- Body mass index in relation to extracellular vesicle-linked microRNAs in human follicular fluid.Fertility and sterility · 2019Article
- Differential gene expression analysis of human cumulus cells.Clinical and experimental reproductive medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Germ cells require communication with associated somatic cells for normal gametogenesis, as exemplified by an oocyte that interacts with granulosa cells via paracrine factors as well as gap junctions located at sites of contact between these two cell types. The objective of the present study was to define the mechanisms by which cell-cell contact with the oocyte is controlled and to determine the extent that the oocyte actively participates in this association. Proline-rich tyrosine kinase 2 (PTK2), a focal adhesion kinase, was found to be activated at sites of contact between the oocyte and trans-zonal cell processes from the surrounding granulosa cells. In order to determine the functional significance of oocyte-derived PTK2 signaling in oocyte-follicle communication, an oocyte-specific Ptk2 knockout was produced through a breeding strategy pairing a floxed Ptk2-CAT-eGFP mouse with the Zp3-Cre line. Since Ptk2-null mice never develop to birth, this represents the first opportunity to define the role of PTK2 in oocyte-follicle communication. Ablation of Ptk2 within the developing oocyte resulted in lower fertility with reduced numbers of pups, lower rates of blastocyst formation, and reduced cell numbers per blastocyst. Follicles containing Ptk2-null oocytes exhibited reduced oocyte diameter, reduced numbers of connexin 37 and 43 foci at the oocyte surface, and impaired dye coupling between oocyte and granulosa cells. These findings are consistent with a model in which PTK2 plays a critical role in establishing or maintaining oocyte-granulosa cell contacts that are essential for gap junction-mediated communication between granulosa cells and the oocyte.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.