Evidence map›Paper›PMID 25539507›Full record

ArticleThe international journal of neuropsychopharmacology2014

Cerebrospinal fluid neuropeptide Y levels in major depression and reported childhood trauma.

Laili Soleimani, Maria A Oquendo, Gregory M Sullivan, Aleksander A Mathé, J John Mann

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genome-wide gene-environment interaction in depression: A systematic evaluation of candidate genes: The childhood trauma working-group of PGC-MDD.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018
    Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Laili SoleimaniDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Dr Soleimani); Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute (Drs Oquendo, Sullivan, and Mann); Department of 3Psychiatry, Columbia University, New York (Drs Oquendo, Sullivan, and Mann); Department of Radiology, Columbia University, New York (Dr Mann); Division of Psychiatry, Karolinska Institute, Stockholm, Sweden (Dr Mathé).
Maria A OquendoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Dr Soleimani); Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute (Drs Oquendo, Sullivan, and Mann); Department of 3Psychiatry, Columbia University, New York (Drs Oquendo, Sullivan, and Mann); Department of Radiology, Columbia University, New York (Dr Mann); Division of Psychiatry, Karolinska Institute, Stockholm, Sweden (Dr Mathé).
Gregory M SullivanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Dr Soleimani); Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute (Drs Oquendo, Sullivan, and Mann); Department of 3Psychiatry, Columbia University, New York (Drs Oquendo, Sullivan, and Mann); Department of Radiology, Columbia University, New York (Dr Mann); Division of Psychiatry, Karolinska Institute, Stockholm, Sweden (Dr Mathé).
Aleksander A MathéDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Dr Soleimani); Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute (Drs Oquendo, Sullivan, and Mann); Department of 3Psychiatry, Columbia University, New York (Drs Oquendo, Sullivan, and Mann); Department of Radiology, Columbia University, New York (Dr Mann); Division of Psychiatry, Karolinska Institute, Stockholm, Sweden (Dr Mathé).
J John MannDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York (Dr Soleimani); Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute (Drs Oquendo, Sullivan, and Mann); Department of 3Psychiatry, Columbia University, New York (Drs Oquendo, Sullivan, and Mann); Department of Radiology, Columbia University, New York (Dr Mann); Division of Psychiatry, Karolinska Institute, Stockholm, Sweden (Dr Mathé). jjm@columbia.edu.
Icahn School of Medicine at Mount Sinai · USNew York State Psychiatric InstituteColumbia University · US

Funding

THE NEUROBIOLOGY OF SUICIDAL BEHAVIORP50MH062185 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2000 to 2009
$21.7M
NIMH NIH HHS MH062185NIMH NIH HHS P50 MH062185
6 · The paper itself

Abstract

backgroundNeuropeptide Y (NPY) may enhance resilience to chronic stress. Low brain NPY reported in major depression may normalize in response to antidepressants.

methodsIn this study, we examined the relationship of reported childhood trauma to cerebrospinal fluid (CSF) NPY-like immunoreactivity (NPY-LI) in 61 medication-free major depressive disorder (MDD) patients and 20 matched healthy volunteers.

resultsHigher CSF NPY-LI was found in MDD compared to the healthy volunteer group (p = 0.01). A positive correlation of CSF NPY-LI with more adverse childhood trauma (p = 0.001) may be indicative of an intact but insufficient NPY-related stress response.

conclusionsWe hypothesize that differences in published results may be explained by the existence of two groups of MDD in terms of CSF NPY levels: MDD with low CSF NPY prior to stress or in response to stress, and those with robust NPY responses to stress. Future studies should confirm the two groups and seek the molecular mechanism for their differences.

Indexed as

Child AbuseAdolescentAdultAgedChildHumansMajor Depressive DisorderMiddle AgedNeuropeptide YSpinal PunctureYoung AdultNeuropeptide Ychildhood traumaCSFmajor depressionneuropeptide Y.

Identifiers

PMID25539507
PMCPMC4368867
OpenAlexW2105891585

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.