SynthesisEuropean journal of pediatrics2015
The effects of estradiol on mood and behavior in human female adolescents: a systematic review.
Synthesis in European journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Trends in non-suicidal self-injury among adolescents: A global cross-temporal meta-analysis, 2007-2023.Psychological medicine · 2025Pooled it
- A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms.Journal of child psychology and psychiatry, and allied disciplines · 2022Pooled it
- Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population.Journal of neuroinflammation · 2018Trial
- Global, regional, and national burden of depression among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021.Archives of women's mental health · 2026Article
- Effects of sex, pubertal stage, and pubertal hormones on frontal and limbic responses to fearful and happy faces during early adolescence.Psychoneuroendocrinology · 2026Article
- Psychosocial interventions for depression and anxiety for female adolescents in Sub-Saharan Africa: a protocol for the systematic literature review and lived experience synthesis.Systematic reviews · 2026Article
- A novel approach for ultrasensitive estradiol detection based on single-layer MXene-based MX@TiOMikrochimica acta · 2026Article
- Disrupted Estrogen Homeostasis Drives Female-Specific Depressive-Like and Anxiety-Like Behaviors via Convergent ERα Downregulation in the Ventral Hippocampus.International journal of biological sciences · 2026Article
- Progesterone and Estradiol Levels Associated with Concussion and Clinical Outcomes and Recovery in Female Athletes and Cadets.Medicine and science in sports and exercise · 2025Article
- The Burden of adolescent depression and the impact of COVID-19 across 204 countries and regions from 1990 to 2021: results from the 2021 global burden of disease study.Scientific reports · 2025Article
- Estrogen and alcohol use in women: a targeted literature review.Archives of women's mental health · 2025Review
- Gender-Specific Trajectories of Non-Suicidal Self-Injury among Adolescents: Predictive Roles of Distal and Proximal Risk Factors.Journal of youth and adolescence · 2025Article
- Identification and Validation of Antidepressant Small Molecules Using Bioinformatics and Mouse Depression Models.Drug design, development and therapy · 2025Article
- Estradiol metabolism by gut microbiota in women's depression pathogenesis: inspiration from nature.Frontiers in psychiatry · 2025Review
- Suicidal behaviour, depression and generalized anxiety and associated factors among female and male adolescents in Mozambique in 2022-23.Child and adolescent psychiatry and mental health · 2024Article
- Neuroactive steroid hormone trajectories across the menstrual cycle in premenstrual dysphoric disorder (PMDD): the PHASE study.Molecular psychiatry · 2024Article
- Pubertal hormones and mental health problems in children and adolescents: a systematic review of population-based studies.EClinicalMedicine · 2024Review
- Within-person biological mechanisms of mood variability in childhood and adolescence.Human brain mapping · 2024Article
- Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents.Development and psychopathology · 2024Article
- Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study.BMC medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledMood disorders and health risk behaviors increase in adolescence. Puberty is considered to contribute to these events. However, the precise impact of pubertal hormone changes to the emergence of mood disorders and risk behaviors is relatively unclear. It is important that inappropriate attribution is not made. Our aim was to determine what is known about the effect of endogenous estradiol on human adolescent girls' mood and behavior. The databases searched were MEDLINE, Embase, PsycINFO, Education Resources Information Center (ERIC), Pre-MEDLINE, Web of Science, and Scopus for all dates to October 2014. For inclusion, contemporaneous hormone and mood or behavioral assessment was required. Data were extracted following a template created by the authors. Fourteen studies met our inclusion criteria. There was some consistency in findings for mood and estradiol levels, with associations between estradiol and depression and emotional tone and risk taking. Results were less consistent for studies assessing other mood and behavioral outcomes. Most studies were cross-sectional in design; assay methodologies used in older studies may lack the precision to detect early pubertal hormone levels.
conclusionThree longitudinal and several cross-sectional studies indicate potential associations between estradiol and certain mood or affective states, especially depression and mood variability though there are insufficient data to confirm that the rise in estradiol during puberty is causative. We believe that it is important for health professionals to take care when attributing adolescent psychopathology to puberty hormones, as the current data supporting these assertions are limited.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.