ArticleEvolutionary applications2011
How evolutionary principles improve the understanding of human health and disease.
Article in Evolutionary applications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 163 citations in OpenAlex.
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- Programming the next generation of prenatal programming of stress research: A review and suggestions for the future of the field.Development and psychopathology · 2024Review
- Placental-Heart Axis: An Evolutionary Perspective.International journal of molecular sciences · 2024Review
- Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging.Integrative and comparative biology · 2023Article
- Explanatory integration and integrated explanations in Darwinian medicine and evolutionary medicine.Theoretical medicine and bioethics · 2023Article
- Toxicity by descent: A comparative approach for chemical hazard assessment.Environmental advances · 2022Article
- Biomolecular Mechanisms of Autoimmune Diseases and Their Relationship with the Resident Microbiota: Friend or Foe?Pathophysiology : the official journal of the International Society for Pathophysiology · 2022Review
- Evolutionary medicine.eLife · 2021Article
- TheFrontiers in medicine · 2021Article
- Desmoplakin: An Important Player in Aging Lung Disease.American journal of respiratory and critical care medicine · 2020Article
- Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana.Science advances · 2020Article
- Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi).Scientific reports · 2020Article
- Science and Religion: Enemies for life?Acta bio-medica : Atenei Parmensis · 2019Article
- The role of the brain-gut-microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders.Brain and behavior · 2019Review
- Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective.International journal of molecular sciences · 2019Article
- The Interplay Between Nutrition and Stress in Pregnancy: Implications for Fetal Programming of Brain Development.Biological psychiatry · 2019Review
- The state of evolutionary medicine in undergraduate education.Evolution, medicine, and public health · 2019Article
- Maternal Stress Potentiates the Effect of an Inflammatory Diet in Pregnancy on Maternal Concentrations of Tumor Necrosis Factor Alpha.Nutrients · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An appreciation of the fundamental principles of evolutionary biology provides new insights into major diseases and enables an integrated understanding of human biology and medicine. However, there is a lack of awareness of their importance amongst physicians, medical researchers, and educators, all of whom tend to focus on the mechanistic (proximate) basis for disease, excluding consideration of evolutionary (ultimate) reasons. The key principles of evolutionary medicine are that selection acts on fitness, not health or longevity; that our evolutionary history does not cause disease, but rather impacts on our risk of disease in particular environments; and that we are now living in novel environments compared to those in which we evolved. We consider these evolutionary principles in conjunction with population genetics and describe several pathways by which evolutionary processes can affect disease risk. These perspectives provide a more cohesive framework for gaining insights into the determinants of health and disease. Coupled with complementary insights offered by advances in genomic, epigenetic, and developmental biology research, evolutionary perspectives offer an important addition to understanding disease. Further, there are a number of aspects of evolutionary medicine that can add considerably to studies in other domains of contemporary evolutionary studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.