ArticleEvolutionary applications2011
The emergence of human-evolutionary medical genomics.
Article in Evolutionary applications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Onco-Breastomics: An Eco-Evo-Devo Holistic Approach.International journal of molecular sciences · 2024Review
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Genetic disease risks can be misestimated across global populations.Genome biology · 2018Article
- Impact of demography and population dynamics on the genetic architecture of human longevity.Aging · 2018Article
- The genome, microbiome and evolutionary medicine.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Understanding rare and common diseases in the context of human evolution.Genome biology · 2016Review
- Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans.Schizophrenia bulletin · 2016Article
- Diabetic embryopathy: a developmental perspective from fertilization to adulthood.Molecular syndromology · 2013Article
- The evolution of evolutionary molecular medicine: genomics are transforming evolutionary biology into a science with new importance for modern medicine.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Functional primate genomics--leveraging the medical potential.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Evolutionary molecular medicine.Journal of molecular medicine (Berlin, Germany) · 2012Review
- The evolutionary biology of child health.Proceedings. Biological sciences · 2011Review
- How evolutionary principles improve the understanding of human health and disease.Evolutionary applications · 2011Article
- Evolutionary principles and their practical application.Evolutionary applications · 2011Article
- In light of evolution: interdisciplinary challenges in food, health, and the environment.Evolutionary applications · 2011Article
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1 author.
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Abstract
In this review, I describe how evolutionary genomics is uniquely suited to spearhead advances in understanding human disease risk, owing to the privileged position of genes as fundamental causes of phenotypic variation, and the ability of population genetic and phylogenetic methods to robustly infer processes of natural selection, drift, and mutation from genetic variation at the levels of family, population, species, and clade. I first provide an overview of models for the origins and maintenance of genetically based disease risk in humans. I then discuss how analyses of genetic disease risk can be dovetailed with studies of positive and balancing selection, to evaluate the degree to which the 'genes that make us human' also represent the genes that mediate risk of polygenic disease. Finally, I present four basic principles for the nascent field of human evolutionary medical genomics, each of which represents a process that is nonintuitive from a proximate perspective. Joint consideration of these principles compels novel forms of interdisciplinary analyses, most notably studies that (i) analyze tradeoffs at the level of molecular genetics, and (ii) identify genetic variants that are derived in the human lineage or in specific populations, and then compare individuals with derived versus ancestral alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.