Evidence map›Paper›PMID 25569346›Full record

ReviewNeuron2015

Genomic perspectives of transcriptional regulation in forebrain development.

Alex S Nord, Kartik Pattabiraman, Axel Visel, John L R Rubenstein

Abstract readReview
In one paragraph

Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Functional maturation of human iPSC-derived pyramidal neuronsFrontiers in cellular neuroscience · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alex S NordDepartment of Neurobiology, Physiology, and Behavior and Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA. Electronic address: asnord@ucdavis.edu.
Kartik PattabiramanDepartment of Psychiatry, Rock Hall, University of California, San Francisco, San Francisco, CA 94158-2324, USA.
Axel ViselGenomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, Merced, CA 95343, USA.
John L R RubensteinDepartment of Psychiatry, Rock Hall, University of California, San Francisco, San Francisco, CA 94158-2324, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1M
Genetic Control of Basal Telencephalic DevelopmentR01MH081880 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 2009 to 2023
$8.1M
Genetic Regulation of Telencephalon DevelopmentR37MH049428 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 2008 to 2017
$5.9M
GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENTR01NS034661 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 1996 to 2015
$4.6M
Research Training for Medical Students & Physician-Scientists in Child PsychiatryR25MH077823 · NIMH · YALE UNIVERSITY · PI ANDRES S MARTIN · 2006 to 2026
$4.0M
A High-Resolution Enhancer Atlas of the Developing ForebrainR01NS062859 · NINDS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER · 2008 to 2010
$1.7M
Developmental and evolutionary dynamics of tissue-specific mammalian enhancers.F32GM105202 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI NORD, ALEXANDER · 2013 to 2014
$60k
NHGRI NIH HHS R01 HG003988NHGRI NIH HHS R01HG003988NIGMS NIH HHS F32 GM105202NIGMS NIH HHS GM105202NIGMS NIH HHS T32 GM007618NIMH NIH HHS R01 MH081880NIMH NIH HHS R01MH081880NIMH NIH HHS R25 MH077823NIMH NIH HHS R37 MH049428NIMH NIH HHS R37MH049428NINDS NIH HHS R01 NS034661NINDS NIH HHS R01 NS062859NINDS NIH HHS R01NS062859ANINDS NIH HHS R01NS34661PHS HHS T32 GMO7618
6 · The paper itself

Abstract

The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. Recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Herein, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.

Indexed as

Enhancer Elements, GeneticGene Expression Regulation, DevelopmentalTranscription FactorsAnimalsEpigenesis, GeneticGenomicsHumansProsencephalonTranscription, GeneticTranscription Factors

Identifiers

PMID25569346
PMCPMC4438709

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.