SynthesisPloS one2015
Fish intake and risk of liver cancer: a meta-analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Fish Consumption and the Risk of Chronic Disease: An Umbrella Review of Meta-Analyses of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Consumption of Fish and ω-3 Fatty Acids and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Fish intake and the risk of brain tumor: a meta-analysis with systematic review.Nutrition journal · 2017Pooled it
- Oral Contraceptives Use and Liver Cancer Risk: A Dose-Response Meta-Analysis of Observational Studies.Medicine · 2015Pooled it
- Dietary risk factors for lung cancer: an umbrella review of systematic review and meta-analysis.Translational cancer research · 2026Review
- Association between Salted Seafood Consumption and Biliary Tract Cancer in Patients Living in the Island Regions of Tokyo: Ecological Study Using Population-based Cancer Registry Data.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Association among occupational class, alcohol consumption, and the risk of hospitalisations due to alcoholic liver diseases: a matched case-control study.BMC public health · 2025Article
- Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study.Discover oncology · 2025Article
- Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies.Annals of translational medicine · 2023Article
- Intake of fish and long-chain n-3 polyunsaturated fatty acids and risk of diseases in a Japanese population: a narrative review.European journal of clinical nutrition · 2021Review
- Development of the anti-cancer food scoring system 2.0: Validation and nutritional analyses of quantitative anti-cancer food scoring model.Nutrition research and practice · 2020Article
- Meat intake and risk of hepatocellular carcinoma in two large US prospective cohorts of women and men.International journal of epidemiology · 2019Article
- The Mediterranean Diet and Cancer: What Do Human and Molecular Studies Have to Say about It?Nutrients · 2019Article
- New and traditional foods in a modernized Mediterranean diet model.European journal of clinical nutrition · 2019Review
- Inverse Association between Glucose‒6‒Phosphate Dehydrogenase Deficiency and Hepatocellular CarcinomaAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Systematic Review and Meta-Analysis on the Association between Polymorphisms in Genes of IL-12 Signaling Pathway and Hepatocellular Carcinoma Risk.Journal of Cancer · 2018Article
- Dietary n-3 polyunsaturated fatty acids, fish consumption, and endometrial cancer risk: a meta-analysis of epidemiological studies.Oncotarget · 2017Article
- Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China.Oncotarget · 2017Article
- New advances in hepatocellular carcinoma.World journal of hepatology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing laboratory findings indicate that n-3 fatty acids, mainly derived from fish, inhibit cancer development and progression, but results from epidemiologic studies have been inconsistent and inconclusive.
objectiveTo evaluate the association of fish intake with risk of liver cancer by conducting a meta-analysis.
methodsPublished case-control/cohort studies that evaluated the relationship between total fish intake and risk of liver cancer were found on PubMed and EMBASE. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were obtained with the random-effects model.
resultsFive retrospective case-control studies and 5 prospective cohort studies were included in the final analysis, involving a total of 3 624 liver cancer cases. Comparing the highest with the lowest category of total fish intake, the pooled RRs of liver cancer were 0.79 (95% CI, 0.59-1.06) for case-control studies, 0.82 (95% CI, 0.70-0.96) for cohort studies and 0.82 (95% CI, 0.71-0.94) for all studies combined. The protective effects of total fish intake against liver cancer were confirmed by stratified and sensitivity analyses. In addition, an increase in fish intake of 1 serving/week was estimated to be significantly associated with 6% lower risk of liver cancer (RR = 0.94, 95% CI, 0.91-0.98).
conclusionsFindings from this meta-analysis suggest that a higher fish intake is associated with reduced risk of liver cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.