ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Plasticity during motherhood: changes in excitatory and inhibitory layer 2/3 neurons in auditory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 89 citations in OpenAlex.
- Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026Article
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- The mouse posterior insular cortex encodes expressive and receptive aspects of courtship vocalizations.Cell reports · 2025Article
- Multisensory integration of social signals by a pathway from the basal amygdala to the auditory cortex in maternal mice.Current biology : CB · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Direct Piriform-to-Auditory Cortical Projections Shape Auditory-Olfactory Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A Cortical Site that Encodes Vocal Expression and Reception.bioRxiv : the preprint server for biology · 2024Article
- Direct piriform-to-auditory cortical projections shape auditory-olfactory integration.bioRxiv : the preprint server for biology · 2024Article
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- Single neuron responses to perceptual difficulty in the mouse auditory cortex.Science advances · 2024Article
- Selective Deletion of Methyl CpG Binding Protein 2 from Parvalbumin Interneurons in the Auditory Cortex Delays the Onset of Maternal Retrieval in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Learning-Induced Odor Modulation of Neuronal Activity in Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Selective deletion ofbioRxiv : the preprint server for biology · 2023Article
- Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex.Neural plasticity · 2023Article
- Surround suppression in mouse auditory cortex underlies auditory edge detection.PLoS computational biology · 2023Article
- Context-Dependent Inhibitory Control of Stimulus-Specific Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Less can be more: Fine tuning the maternal brain.Neuroscience and biobehavioral reviews · 2022Review
- Hearing, touching, and multisensory integration during mate choice.Frontiers in neural circuits · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal behavior can be triggered by auditory and olfactory cues originating from the newborn. Here we report how the transition to motherhood affects excitatory and inhibitory neurons in layer 2/3 (L2/3) of the mouse primary auditory cortex. We used in vivo two-photon targeted cell-attached recording to compare the response properties of parvalbumin-expressing neurons (PVNs) and pyramidal glutamatergic neurons (PyrNs). The transition to motherhood shifts the average best frequency of PVNs to higher frequency by a full octave, with no significant effect on average best frequency of PyrNs. The presence of pup odors significantly reduced the spontaneous and evoked activity of PVN. This reduction of feedforward inhibition coincides with a complimentary increase in spontaneous and evoked activity of PyrNs. The selective shift of PVN frequency tuning should render pup odor-induced disinhibition more effective for high-frequency stimuli, such as ultrasonic vocalizations. Indeed, pup odors increased neuronal responses of PyrNs to pup ultrasonic vocalizations. We conclude that plasticity in the mothers is mediated, at least in part, via modulation of the feedforward inhibition circuitry in the auditory cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.